Christopher Yau DPhil

Group Leader in Genomic Medicine

Wellcome Trust Centre for Human Genetics, University of Oxford

Location
Oxford, United Kingdom
Discipline
Mathematics
Interests
Bioinformatics, Genetics, Cancer, Mathematical and Statistical Modelling, Bayesian Statistics, Markov Chain Monte Carlo methods, Sequential Monte Carlo methods, Image Processing, Signal Processing, Parallel Computing methods.
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  • 11 Followers

About

I am currently a Group Leader in Genomic Medicine in the Wellcome Trust Centre for Human Genetics at the University of Oxford. My research interests are in statistical methods development for genomics.
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Publications

  • On the Utility of Graphics Cards to Perform Massively Parallel Simulation of Advanced Monte Carlo Methods

    Lee A, Yau C, Giles M, Doucet A, Holmes C

    Journal of Computational and Graphical Statistics (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Bayesian non‐parametric hidden Markov models with applications in genomics.

    Yau C, Papaspiliopoulos O, Roberts G, Holmes C

    Journal of the Royal Statistical Society: Series B (Statistical Methodology) (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A decision-theoretic approach for segmental classification

    Yau C, Holmes C

    The Annals of Applied Statistics (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.

    Mouradov D, Domingo E, Gibbs P, Jorissen R, Li S, Soo P et al.

    The American journal of gastroenterology (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A sequential algorithm for fast fitting of Dirichlet process mixture models

    Nott D, Zhang X, Yau C, Jasra A

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The Alive Particle Filter

    Jasra A, Lee A, Yau C, Zhang X

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • OncoSNP-SEQ: a statistical approach for the identification of somatic copy number alterations from next-generation sequencing of cancer genomes.

    Yau C

    Bioinformatics (Oxford, England) (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • NucleoFinder: a statistical approach for the detection of nucleosome positions.

    Becker J, Yau C, Hancock J, Holmes C

    Bioinformatics (Oxford, England) (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion.

    Sengupta N, Yau C, Sakthianandeswaren A, Mouradov D, Gibbs P, Suraweera N et al.

    Molecular cancer (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

    Craddock N, Hurles M, Cardin N, Pearson R, Plagnol V, Robson S et al.

    Nature (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Quantification of subclonal distributions of recurrent genomic aberrations in paired pre-treatment and relapse samples from patients with B-cell chronic lymphocytic leukemia.

    Knight S, Yau C, Clifford R, Timbs A, Sadighi Akha E, Dréau H et al.

    Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2012)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Hierarchical Bayesian nonparametric mixture models for clustering with variable relevance determination

    Yau C, Holmes C

    Bayesian Analysis (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data.

    Yau C, Mouradov D, Jorissen R, Colella S, Mirza G, Steers G et al.

    Genome biology (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Presynaptic NMDARs in the Hippocampus Facilitate Transmitter Release at Theta Frequency.

    McGuinness L, Taylor C, Taylor R, Yau C, Langenhan T, Hart M et al.

    Neuron (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Signal Processing for Genomics

    Holmes C, Yau C

    ieeexplore.ieee.org

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A decision theoretic approach for segmental classification using Hidden Markov Models

    Yau C, Holmes C

    oxford-man.ox.ac.uk (2009)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • CNV discovery using SNP genotyping arrays

    Yau C, Holmes C

    Cytogenet Genome Res (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A Recursive, Stochastic Vessel Segmentation Framework that Robustly Handles Bifurcations

    Allen K, Yau C, Noble A

    Proceedings of the 12th Annual Conference on Medical Image Understanding and Analysis 2008 (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data.

    Colella S, Yau C, Taylor J, Mirza G, Butler H, Clouston P et al.

    Nucleic acids research (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Akt regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo.

    Buttrick G, Beaumont L, Leitch J, Yau C, Hughes J, Wakefield J

    The Journal of cell biology (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Comparing CNV detection methods for SNP arrays.

    Winchester L, Yau C, Ragoussis J

    Briefings in functional genomics & proteomics (2009)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • GenoSNP: a variational Bayes within-sample SNP genotyping algorithm that does not require a reference population.

    Giannoulatou E, Yau C, Colella S, Ragoussis J, Holmes C

    Bioinformatics (Oxford, England) (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Quantitative Image Analysis of Chromosome Dynamics in Early Drosophila Embryos

    Yau C, Wakefield J

    The Fourth IEEE International Symposium on Biomedical Imaging (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Professional experience

Group Leader in Genomic Medicine

Wellcome Trust Centre for Human Genetics, University of Oxford

October 2013 - Present

Lecturer in Statistics

Department of Mathematics, Imperial College London

January 2012 - September 2013 (1 year 8 months)

Research Fellow

University of Oxford

April 2009 - December 2011 (2 years 8 months)

Postdoctoral Scientist

Wellcome Trust Centre for Human Genetics, University of Oxford

October 2008 - March 2009 (5 months)

Education history

University of Oxford

DPhil

October 2004 - March 2009 (4 years 5 months)

Trinity College, University of Cambridge

MEng

October 2000 - June 2004 (3 years 8 months)