I Studied chemistry and biology at Utrecht University, specialising in biochemistry and cell biology in the group of Paul van Bergen en Henegouwen and Arie Verkleij. During an internship with Peter Laird (USC, Los Angeles), I worked in a lab that combines mouse model work with genome-wide DNA methylation studies. During my PhD with Madelon Maurice (UMC Utrecht), I focused on molecular mechanisms in Wnt signalling, which is important in development, homeostasis and cancer. We made an interesting new connection between the fields of ubiquitin-mediated protein regulation, Wnt signalling, and skin tumorigenesis.
Now I am a postdoctoral fellow in the lab of Eduard Batlle (IRB Barcelona), where intestinal (cancer) stem cells and the tumour microenvironment (TME) are the main areas of research, and the group is making important contributions to the identification and targeting of stromal TGF-beta as a pro-metastatic master regulator in colorectal cancer. My projects centre on further dissecting the crosstalk mechanisms in the TME that drive metastasis, developing and using novel metastatic mouse models and synthetic chemistry.
Determinants of metastatic competency in colorectal cancer