David Briggs PhD Protein Crystallography

Post Doc

Imperial College London

City
London, United Kingdom
Discipline
Biological Sciences
Interests
Proteoglycans, Structural Biology, Interaction analysis, Crystallography, SAXS
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About

A protein crystallographer and biophysicist with training in small angle X-ray scattering and many different interaction analysis techniques, such as isothermal titration calorimetry and surface plasmon resonance.

I am currently employed at Imperial College London, in the group of Prof Erhard Hohenester, using these skills to investigate the Laminin family of extracellular matrix proteins.
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Publications

  • Inter-α-inhibitor Impairs TSG-6-induced Hyaluronan Cross-linking.

    Baranova N, Foulcer S, Briggs D, Tilakaratna V, Enghild J, Milner C et al.

    The Journal of biological chemistry (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.

    Boëda B, Knowles P, Briggs D, Murray-Rust J, Soriano E, Garvalov B et al.

    The Journal of biological chemistry (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Crystallization and preliminary crystallographic analysis of the Clostridium perfringens enterotoxin.

    Briggs D, Smedley J, McClane B, Basak A

    Acta crystallographica. Section F, Structural biology and crystallization communications (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins.

    Briggs D, Naylor C, Smedley J, Lukoyanova N, Robertson S, Moss D et al.

    Journal of molecular biology (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers

    Baranova N, Nilebäck E, Haller F, Briggs D, Svedhem S, Day A et al.

    The Journal of biological chemistry (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Clostridium absonum α-Toxin: New Insights into Clostridial Phospholipase C Substrate Binding and Specificity

    Clark G, Briggs D, Karasawa T, Wang X, Cole A, Maegawa T et al.

    Journal of Molecular Biology (2003)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2

    Inforzato A, Baldock C, Jowitt T, Holmes D, Lindstedt R, Marcellini M et al.

    The Journal of biological chemistry (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding.

    Boëda B, Briggs D, Higgins T, Garvalov B, Fadden A, McDonald N et al.

    Molecular cell (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A bug in CUB's clothing: similarity between clostridial CBMs and complement CUBs

    Briggs D, Day A

    Trends in Microbiology (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

    Fox G, Shafiq M, Briggs D, Knowles P, Collister M, Didmon M et al.

    Nature (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Structural relationships and cellular tropism of staphylococcal superantigen-like proteins

    Al-Shangiti A, Naylor C, Nair S, Briggs D, Henderson B, Chain B

    Infection and Immunity (2004)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Professional experience

Post Doc

Imperial College London

August 2014 - Present

Post Doc

Faculty of Life Sciences, University of Manchester

November 2006 - July 2014 (7 years 8 months)

Post Doc

Cancer Research UK, London Research Institute

April 2004 - October 2006 (2 years 6 months)

Education history

Birkbeck College, University of London

PhD Protein Crystallography

September 2001 - April 2004 (2 years 7 months)

Birkbeck College, University of London

MRes Structural Biology

September 2000 - September 2001 (1 year)

University of Birmingham

BSc Biochemistry and Biotechnology

September 1996 - June 2000 (3 years 9 months)