David Briggs

  • PhD Protein Crystallography
  • Researcher
  • Post Doc
  • Imperial College London
  • Agricultural and Biological Sciences

Research Interests

Proteoglycans Structural Biology Interaction analysis Crystallography SAXS

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About

A protein crystallographer and biophysicist with training in small angle X-ray scattering and many different interaction analysis techniques, such as isothermal titration calorimetry and surface plasmon resonance.

I am currently employed at Imperial College London, in the group of Prof Erhard Hohenester, using these skills to investigate the Laminin family of extracellular matrix proteins.
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Publications

Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1–4

Paracuellos P, Briggs D, Carafoli F, Lončar T, Hohenester E

Structure (2015)

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Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix *

Briggs D, Birchenough H, Ali T, Rugg M, Waltho J, Ievoli E, et al.

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A Refined Model for the TSG-6 Link Module in Complex with Hyaluronan USE OF DEFINED OLIGOSACCHARIDES TO PROBE STRUCTURE AND FUNCTION *

Higman V, Briggs D, Mahoney D, Blundell C, Sattelle B, Dyer D, et al.

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Incorporation of Pentraxin 3 into Hyaluronan Matrices Is Tightly Regulated and Promotes Matrix Cross-linking

Baranova N, Inforzato A, Briggs D, Tilakaratna V, Enghild J, Thakar D, et al.

Published JBC Papers in Press (2014)

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Structure of the Food-Poisoning Clostridium perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming Toxins

Briggs D, Naylor C, Smedley Iii J, Lukoyanova N, Robertson S, Moss D, et al.

Journal of Molecular Biology (2011)

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A bug in CUB's clothing: similarity between clostridial CBMs and complement CUBs

Briggs D, Day A

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Clostridium absonum a-Toxin: New Insights into Clostridial Phospholipase C Substrate Binding and Specificity

Clark G, Briggs D, Karasawa T, Wang X, Cole A, Maegawa T, et al.

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J. Biol. Chem.-2013-Baranova-29642-53

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LETTERS Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

Fox G, Shafiq M, Briggs D, Knowles P, Collister M, Didmon M, et al.

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Tes, a Specific Mena Interacting Partner, Breaks the Rules for EVH1 Binding

Boë Da B, Briggs D, Higgins T, Garvalov B, Fadden A, Mcdonald N, et al.

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Professional experience

Post Doc

Imperial College London

August 2014 - Present

Post Doc

University of Manchester Faculty of Life Sciences

November 2006 - July 2014 (7 years 8 months)

Post Doc

Cancer Research UK, London Research Institute

April 2004 - October 2006 (2 years 6 months)

Education history

Birkbeck College, University of London

PhD Protein Crystallography

September 2001 - April 2004 (2 years 7 months)

Birkbeck College, University of London

MRes Structural Biology

September 2000 - September 2001 (1 year)

University of Birmingham

BSc Biochemistry and Biotechnology

September 1996 - June 2000 (3 years 9 months)