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Dominik Haudenschild

  • PhD
  • Professor
  • University of California Davis Health System Department of Orthopaedic Surgery
  • 21h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 2092CitationsNumber of citations received by Dominik's publications. Updated daily.

About

We study early responses to joint injury to learn about the pathogenesis of osteoarthritis and to identify intervention strategies. We study chondrocyte mechanobiology to understand how mechanical forces are translated into biochemical responses. We study cartilage matricellular proteins to gain insight into how cells interact with growth factors and the extracellular matrix. We use animal models of joint injury and bone formation, explant models of osteochondral injuries, stem-cell based tissue engineering, and 3-axis bioreactors to mechanically stimulate hydrogel-embedded chondrocytes and stem cells. We apply the knowledge to translational studies. Example: Intervene with inflammatory gene expression upon joint injury to prevent or delay OA. Example: Enhance BMP-mediated bone regeneration by presenting the growth factor in a biologically relevant context on matricellular proteins.

Editorships

PLoS

Academic Editor

2019 - Present

Journal of Orthopaedic Research

Editorial Review Board

2016 - Present

Recent publications

  • Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes

    N/AReaders
    N/ACitations
  • Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis

    N/AReaders
    N/ACitations

Professional experience

Professor

University of California Davis Health System Department of Orthopaedic Surgery

July 2018 - Present

Assistant Professor

University of California Davis Health System Department of Orthopaedic Surgery

September 2008 - June 2014(6 years)

Post-doc and Adjunct Assistant Prof

The Scripps Research Institute

June 2005 - August 2008(3 years)

Research

Genzyme Science Center

January 1995 - January 1998(3 years)

Education

Ph.D.

University of California - Davis

September 1999 - March 2003(4 years)

B.A.

Boston University

September 1985 - June 1989(4 years)

Co-authors (132)

  • Blaine Christiansen