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Emanuele Buratti

  • PHD
  • Group leader
  • International Centre for Genetic Engineering and Biotechnology
  • 54h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 11794CitationsNumber of citations received by Emanuele's publications. Updated daily.


Ever since the beginning of my post-doctoral work my principal areas of expertise have been the investigation of RNA binding proteins/structure and their influence on translation and alternative splicing processes. In 2001, as part of a research project on Cystic Fibrosis, I identified nuclear protein TDP-43 as a potential CFTR exon 9 pre-mRNA splicing regulator. As a result, in the following years I have performed several basic studies on the biochemical and functional properties of this protein (see section C) that have been of great advantage to the scientific community when its role in neurodegeneration was first reported in 2006. Since then, my research has been primarily focused at investigating the potential pathophysiological role played by TDP-43 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis and in better understanding the functional roles played by this protein (ie. microRNA biogenesis and splicing regulation, shuttling nuclear/cytosplamic properties, autoregulatory processes etc.).


Frontiers in Genetics and Frontiers in Molecular Biosciences

Associate Editor

2017 - Present

Journal of Biological Chemistry

Editorial Board member

2015 - Present

Recent publications

  • Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis

    • Fratta P
    • Sivakumar P
    • Humphrey J
    • et al.
  • TDP-43 post-translational modifications in health and disease

    • Buratti E

Professional experience

Group leader

International Centre For Genetic Engineering and Biotechnology

January 2013 - Present

Professional Staff Scientist

International Centre For Genetic Engineering and Biotechnology

January 1997 - January 2013(16 years)


International Centre For Genetic Engineering and Biotechnology

January 1993 - January 1997(4 years)


PhD in Biochemistry

Universita degli Studi di Trieste

January 1989 - January 1993(4 years)

Degree in Biological Sciences

Universita degli Studi di Trieste

January 1984 - January 1989(5 years)

Co-authors (476)