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Emmanuel Datan

  • @ THE JOHNS HOPKINS UNIV. SCHOOL OF MEDICINE
  • Member
  • American Association for the Advancement of Science
  • 4h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 192CitationsNumber of citations received by Emmanuel's publications. Updated daily.

Other IDs

Research interests

Behavioral changes due to diseasePlant products for drug discovery/developmentEpigeneticsProtein CrystallographyNeuroscienceCell deathInfectious disease (by viruses)Autophagy regulationChemical BiologyProtein function/activity/regulation

About

I started research work during high school when I interviewed and collated facts from a community of small scale fishermen in the Philippines. My next work involved understanding how physical (ground salinity, temperature, pH) and biological (tree species diversity, tree biomass, forest patchiness) parameters of a Mangrove forest affected bird diversity and distribution. After working at the macromolecular level I engaged in molecular biology studying how viruses like influenza A or dengue and modoc viruses uniquely trigger a cell's death or stress response program to maximize reproduction. An interlude of research projects at different institutions have laced my scientific path: 1. Mapping regions essential for protein-protein interaction between Bcl-xL and Aven while at J.M. Hardwick's lab at The Johns Hopkins University, Baltimore, MD. 2. Expression, Purification and Crystal screening of novel histone H3.3 chaperone Daxx at C.D. Allis' lab at The Rockefeller University, NY, NY. 3. Explored the effects of different viral genes on neuroblastoma cells at S. Fulda's lab at the Institute for Experimental Cancer Research in Pediatrics - Goethe-University, Frankfurt, Germany. With my team at Queens College, We explored the subtleties of autophagy regulation during viral infection (Cell Death and Disease, 7(e2127):1-10, 2016; Virology, 452-453:175-190, 2014; World J Biol Chem, 5(2): 93-105, 2014; J. Biol. Chem, 286:22147-22159, 2011). I look forward to seeing the application of our findings on autophagy and cell death in drug design and development. Let's collaborate! In lieu of my plan and dream of having my own lab that focuses on therapeutics/cure, I am currently in the laboratory of chemical biology headed by Dr. Jun O. Liu at Johns Hopkins University School of Medicine to develop a better understanding of human disease/s and learn skills for independent/self-driven yet collaborative research. Feel free to message me here about research and I will get back to you as soon as I can!

Groups

Co-authors (16)

Publications (5)

  • 20 Years of Cell Death - Chapter15 (Cell death and virus infection – a short review)

    • Zakeri Z
    • Ghosh-Roy S
    • Datan E
    • et al.
    N/AReaders
    N/ACitations
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  • Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation

    • Datan E
    • Roy S
    • Germain G
    • et al.
    N/AReaders
    N/ACitations
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  • mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection

    • Datan E
    • Shirazian* A
    • Benjamin* S
    • et al.
    N/AReaders
    N/ACitations
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  • Regulation of cell survival and death during Flavivirus infections

    • Ghosh Roy S
    • Datan* E
    • Sadigh* B
    • et al.
    N/AReaders
    N/ACitations
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  • Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication

    • McLean J
    • Wudzinska A
    • Datan E
    • et al.
    N/AReaders
    103Citations
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Professional experience

Member

American Association for the Advancement of Science

January 2015 - Present

Member

American Society for Pharmacolgy and Experimental Therapeutics

September 2014 - Present

Member

American Society for Microbiology

November 2009 - Present

Publication citation list are

scholar.google.com/citations?user=vSPBvwcAAAAJ&hl=en&oi=ao

January 2009 - Present