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Enrique Hernandez-Lemus

  • Ph.D.
  • Principal Investigator - Lead Researcher
  • National Institute of Genomic Medicine
  • 34PublicationsNumber of items in Enrique's My Publications folder on Mendeley.
  • 8Followers

Research interests

Probability and Measure TheoryErgodic TheoryMathematical PhysicsChemical PhysicsTheoretical BiologyData MiningComputational IntelligenceProbability TheoryStatistical PhysicsComputational GenomicsSystems Biology

About

During his doctorate, Professor Hernández-Lemus worked in theoretical chemical physics and non-equilibrium statistical physics. In particular, he developed an irreversible thermodynamics formalism to study molecular systems in the critical point far from equilibrium. In the context of this formalism, by extending ideas from measure theory and mathematical statistical mechanics, he was able to derive correlation functions for non-equilibrium systems without using equilibrium closures (such as the Ornstein-Zernike). This work was the first fully-analytical study, free from adjustable parameters, to describe appropriately (both quantitatively and qualitatively) the critical co-solution transition for a binary mixture with its associated transport processes [Hernández-Lemus, E. García-Colín, L.S., Non-equilibrium critical behavior: An extended irreversible thermodynamics approach, Jou. of Non-Equil. Thermodyn., 31, 4, 397-417, (2006)]. Within biological physics and computational systems biology, current research includes the development of a non-equilibrium thermodynamics theoretical framework to study whole genome transcriptional regulation in eukaryotes (humans in particular) [Hernández-Lemus, E., Non-Equilibrium Thermodynamics of Gene Expression and Transcriptional Regulation, Jou. of Non-Equil. Thermodyn., 34, 4, 371-394, (2009)]. This theoretical framework has been used to analyze transcriptional bursts and their relation with anomalous gene expression in cancer [Hernández-Lemus, E., Correa-Rodríguez, M.D., Non-equilibrium hyperbolic transport in transcriptional regulation, PLoS ONE 6, 7, e21558 (2011)] and their role in specific genes at the coupling between metabolic disruption and cancer [Baca-López, K., Hidalgo-Miranda, A., Mayorga, M., Gutiérrez-Nájera, N.,Hernández-Lemus, E., The role of master regulators in the metabolic/ transcriptional coupling in breast carcinomas, PLoS ONE 7, 8, e42678, (2012)]. Aside from individual developments, Professor Hernández-Lemus has been also involved in the statistical and computational design of high-end experimental projects such as the Mexican Genome Project (Mexican Genome Diversity and Genomic Medicine Project) [Silva-Zolezzi I, et al., Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico. PNAS 106, 21, 8611- 8616, (2009)] and the sequencing of the genome of diffuse large B-cell lymphoma cells [Lohr, J., et al., Discovery and Prioritization of Somatic Mutations in DLBCL by Whole Exome Sequencing, PNAS 109, 10, 3879-3884, (2012)]. Dr. Hernández- Lemus is also a strong advocate for OpenScience/OpenAccess [He is Academic Editor at PLoS ONE and Review Editor at Frontiers in Physiology] and has devoted special efforts to spread the role of theoretical physics (specially statistical mechanics and complex systems) in the biomedical research community within his country.

Followers (8)

  • Pedro C. Hidalgo

    Pedro C. HidalgoUniversidad de la Republica Uruguay- Centro Universitario de Tacuarembó

  • Hugo Leonid Gallardo Blanco

    Hugo Leonid Gallardo BlancoAutonomous University of Nuevo Leon

  • Ramces Falfan-Valencia

    Ramces Falfan-ValenciaInstituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas

  • Sergio A. Alcalá-Corona

    Sergio A. Alcalá-CoronaNational Institute of Genomic Medicine

  • J. Mario Siqueiros-García

    J. Mario Siqueiros-GarcíaIIMAS, UNAM (Research Institute of Applied Mathematics and Systems of the National University of México)

  • Hugo Tovar

    Hugo TovarNational Institute of Genomic Medicine

Explore network

Following (3)

  • Hugo Tovar

    Hugo TovarNational Institute of Genomic Medicine

  • J. Mario Siqueiros-García

    J. Mario Siqueiros-GarcíaIIMAS, UNAM (Research Institute of Applied Mathematics and Systems of the National University of México)

  • Rodrigo Galindo-Murillo

    Rodrigo Galindo-MurilloUniversity of Utah College of Pharmacy

Publications (5)

  • Biophysics of active vesicle transport, an intermediate step that couples excitation and exocytosis of serotonin in the neuronal soma

    • De Miguel F
    N/AReaders
    N/ACitations
  • Extrasynaptic release of serotonin affects the social dynamics of leeches

    • Hernández-Lemus E
    N/AReaders
    N/ACitations
  • Non-equilibrium thermodynamics of cell signaling

    • Hernández-Lemus E
    N/AReaders
    N/ACitations
  • The role of master regulators in the metabolic/transcriptional coupling in breast carcinomas

    • Baca-López K
    • Hidalgo-Miranda A
    • Mayorga M
    • et al.
    N/AReaders
    N/ACitations
  • Transcriptional network structure assessment via the Data Processing Inequality

    • Hernández-Lemus E
    N/AReaders
    N/ACitations

Professional experience

Principal Investigator - Lead Researcher

National Institute of Genomic Medicine

June 2013 - Present

Full researcher

National Institute of Genomic Medicine

June 2009 - June 2013(4 years)

Associate Researcher

National Institute of Genomic Medicine

October 2006 - June 2009(3 years)

Education history

PhD (Chemical Physics)

Universidad Nacional Autónoma de México, UNAM

February 1999 - October 2006(8 years)