Eric di Luccio Ph.D.

Associate Professor

Kyungpook National University

City
Daegu, South Korea
Discipline
Biological Sciences
Interests
Structural Biology, Biophysics, Biochemistry, X-ray crystallography, Bioinformatics, Epigenetic therapy of cancers, Transcriptional regulation, Structure-based drug design
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About

I am an associate professor, with background in structural biology, biochemistry, genetic and protein engineering, bioinformatics, computational biology, drug-design, epigenetic therapy of cancers. I have an extensive experience in interdisciplinary scientific collaborations.

My laboratory studies the functions, structures, and mechanisms of transcription factors for developing new drugs against cancers, neurodegenerative diseases, and stroke. Work in my research group is multi-disciplinary and it incorporates many processes of the early-stage drug development.

My research is at the interface between biochemistry, pharmacology, neuroscience, structural biology, and computational biology. Methods development concerns news tools in bioinformatics and molecular modeling of proteins for our research needs.

Prior joining the Kyungpook National University, I was a postdoctoral researcher at the University of California (USA) at Davis consecutively in David K. Wilson's lab (Molecular and Cellular biology dept.) and in Patrice Koehl's lab (Genome center).
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Publications

  • In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L

    Morishita M, Mevius D, di Luccio E

    BMC Structural Biology (2014)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Crystallographic Observation of pH-Induced Conformational Changes in the Amyelois transitella Pheromone-Binding Protein AtraPBP1

    di Luccio E, Ishida Y, Leal W, Wilson D

    PLoS ONE (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The H-factor as a novel quality metric for homology modeling.

    di Luccio E, Koehl P

    Journal of clinical bioinformatics (2012)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Structural insights into the regulation and the recognition of histone marks by the SET domain of NSD1.

    Morishita M, Luccio E

    Biochemical and biophysical research communications (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Cancers and the NSD family of histone lysine methyltransferases.

    Morishita M, di Luccio E

    Biochimica et biophysica acta (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Thèses de doctorat (Ph.D Thesis)

    di Luccio E

    Le Temps des médias (2003)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Evolution of maurotoxin conformation and blocking efficacy towards Shaker B channels during the course of folding and oxidation in vitro

    Di Luccio E, Matavel A, Opi S, Regaya I, Sandoz G, M'barek S et al.

    Biochemical Journal (2002)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Maurotoxin versus Pi1/HsTx1 scorpion toxins. Toward new insights in the understanding of their distinct disulfide bridge patterns.

    Fajloun Z, Mosbah a, Carlier E, Mansuelle P, Sandoz G, Fathallah M et al.

    The Journal of biological chemistry (2000)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels.

    Fajloun Z, Carlier E, Lecomte C, Geib S, Di Luccio E, Bichet D et al.

    European journal of biochemistry / FEBS (2000)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels.

    M'Barek S, Lopez-Gonzalez I, Andreotti N, di Luccio E, Visan V, Grissmer S et al.

    The Journal of biological chemistry (2003)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Disulfide bridge reorganization induced by proline mutations in maurotoxin.

    Carlier E, Fajloun Z, Mansuelle P, Fathallah M, Mosbah a, Oughideni R et al.

    FEBS letters (2001)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Synthesis, 1H NMR structure, and activity of a three-disulfide-bridged maurotoxin analog designed to restore the consensus motif of scorpion toxins.

    Fajloun Z, Ferrat G, Carlier E, Fathallah M, Lecomte C, Sandoz G et al.

    The Journal of biological chemistry (2000)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ryanodine receptors.

    Fajloun Z, Kharrat R, Chen L, Lecomte C, Di Luccio E, Bichet D et al.

    FEBS letters (2000)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Comprehensive X-ray structural studies of the quinolinate phosphoribosyl transferase (BNA6) from Saccharomyces cerevisiae.

    di Luccio E, Wilson D

    Biochemistry (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies.

    Di Luccio E, Elling R, Wilson D

    The Biochemical journal (2006)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Molecular modeling and docking simulations of scorpion toxins and related analogs on human SKCa2 and SKCa3 channels.

    Andreotti N, di Luccio E, Sampieri F, De Waard M, Sabatier J

    Peptides (2005)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Parameters affecting in vitro oxidation/folding of maurotoxin, a four- disulphide-bridged scorpion toxin

    di Luccio E, Azulay D, Regaya I, Fajloun Z, Sandoz G, Mansuelle P et al.

    Biochemical Journal (2001)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Structural and kinetic studies of induced fit in xylulose kinase from Escherichia coli.

    Di Luccio E, Petschacher B, Voegtli J, Chou H, Stahlberg H, Nidetzky B et al.

    Journal of molecular biology (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Effect of Cu2+ on the oxidative folding of synthetic maurotoxin in vitro.

    Regaya I, Andreotti N, Di Luccio E, De Waard M, Sabatier J

    Journal of biomolecular structure & dynamics (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Nrf2-mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae.

    Kim H, di Luccio E, Kong A, Kim J

    Biotechnology journal (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A quality metric for homology modeling: the H-factor.

    di Luccio E, Koehl P

    BMC bioinformatics (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Professional experience

Associate Professor

Kyungpook National University

April 2014 - Present

Assistant Professor

Kyungpook National University

January 2010 - March 2014 (4 years 2 months)

Postdoc

University of California - Davis

November 2003 - December 2009 (6 years 1 month)

Education history

Université Aix-Marseille II / CNRS

Ph.D. Neuroscience / structural biology

September 2000 - October 2003 (3 years 1 month)

Université Aix-Marseille II / CNRS

M.Sc in Neuroscience / structural biology

September 1999 - June 2000 (9 months)

Université de Limoges

B.S Biochemistry

September 1995 - June 1999 (3 years 9 months)