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Felix Machin

  • PhD
  • Group Leader
  • Hospital Universitario Nuestra Señora de Candelaria
  • 17h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 850CitationsNumber of citations received by Felix's publications. Updated daily.

Other IDs

Research interests

CancerSaccharomyces cerevisiaeRad9Rad52CondensinMus81-Mms4Yen1Top2Cdc14MitosisDNA damage and repairChromosome structure and segregation


Genomic instability leads to cancer. Also genomic instability promotes diversity of the malignant cells within the tumour. DNA damage and chromosome nondisjunction are the two major causes of gross instability. We aim to study both problems and their relationship with the life and death of the cell. We use the model organism Saccharomyces cerevisiae as well as actual tumour tissues to gain insights into the complexity of the maintenance of the integrity of the genome. We are also interested in drugs that affect the DNA and their effects on how the can reshape the genome.

Co-authors (98)

  • Silvia M. Santana-Sosa
  • Karla Suzana Moresco
  • Evgeny Denisov
  • kate gibbs
  • Oliver Quevedo
  • Jonay García

Recent publications

  • Lawsone, Juglone, and β-Lapachone Derivatives with Enhanced Mitochondrial-Based Toxicity.

    • Anaissi-Afonso L
    • Oramas-Royo S
    • Ayra-Plasencia J
    • et al.
    Get full text
  • TORC1, stress and the nucleolus.

    • Matos-Perdomo E
    • Machín F
    Get full text

Professional experience

Group Leader

Hospital Universitario Nuestra Señora de Candelaria

December 2005 - Present