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Felix Machin

  • PhD
  • Group Leader
  • Hospital Universitario Nuestra Señora de Candelaria
  • 16h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 803CitationsNumber of citations received by Felix's publications. Updated daily.

Other IDs

Research interests

CancerSaccharomyces cerevisiaeRad9Rad52CondensinMus81-Mms4Yen1Top2Cdc14MitosisDNA damage and repairChromosome structure and segregation

About

Genomic instability leads to cancer. Also genomic instability promotes diversity of the malignant cells within the tumour. DNA damage and chromosome nondisjunction are the two major causes of gross instability. We aim to study both problems and their relationship with the life and death of the cell. We use the model organism Saccharomyces cerevisiae as well as actual tumour tissues to gain insights into the complexity of the maintenance of the integrity of the genome. We are also interested in drugs that affect the DNA and their effects on how the can reshape the genome.

Co-authors (95)

  • Silvia M. Santana-Sosa
  • Karla Suzana Moresco
  • Evgeny Denisov
  • kate gibbs
  • Oliver Quevedo
  • Jonay García

Publications (5)

  • Lawsone, Juglone, and β-Lapachone Derivatives with Enhanced Mitochondrial-Based Toxicity.

    • Anaissi-Afonso L
    • Oramas-Royo S
    • Ayra-Plasencia J
    • et al.
    N/AReaders
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  • The ribosomal DNA metaphase loop of Saccharomyces cerevisiae gets condensed upon heat stress in a Cdc14-independent TORC1-dependent manner

    • Matos-Perdomo E
    • Machín F
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  • TORC1, stress and the nucleolus.

    • Matos-Perdomo E
    • Machín F
    N/AReaders
    N/ACitations
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  • Synthesis and antibacterial activity of new symmetric polyoxygenated dibenzofurans

    • Oramas-Royo S
    • Pantoja K
    • Amesty Á
    • et al.
    N/AReaders
    N/ACitations
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  • Condensin Regulates rDNA Silencing by Modulating Nucleolar Sir2p

    • Machín F
    • Paschos K
    • Jarmuz A
    • et al.
    N/AReaders
    49Citations
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Professional experience

Group Leader

Hospital Universitario Nuestra Señora de Candelaria

December 2005 - Present