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Filipe Freire

  • PhD
  • Senior Research Associate
  • Instituto de Biologia Experimental e Tecnológica - iBET
  • 3h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 20CitationsNumber of citations received by Filipe's publications. Updated daily.

Research interests

Structure based drug designProtein-ligand interactionsX-ray CrystallographyEndolysinProtein NMR

About

Three-dimensional structures of biological molecules lie at the very core of understanding biochemical and biological processes, at the atomic level. My research interests have been centered on the study of the three-dimensional structure of proteins and protein-ligand interactions using X-ray Crystallography and Nuclear Magnetic Resonance. Over the past years I have been involved in several projects including: - Protein crystallography applied to drug design; - Structural and biochemical characterization of endolysins; - Functional and structural characterization of a megaDalton complex, the Cellulosome, present in some anaerobic bacteria and fungi.

Co-authors (31)

  • Diana Vieira
  • Marcia Correia
  • Ana Luisa Carvalho
  • Benedita Pinheiro
  • Fábio Madeira

Recent publications

  • The crystal structure of the R280K mutant of human p53 explains the loss of DNA binding

    • Gomes A
    • Trovão F
    • Andrade Pinheiro B
    • et al.
    N/AReaders
    0Citations
    Get full text
  • Conservation in the mechanism of glucuronoxylan hydrolysis revealed by the structure of glucuronoxylan xylanohydrolase (CtXyn30A) from Clostridium thermocellum

    • Freire F
    • Verma A
    • Bule P
    • et al.
    N/AReaders
    4Citations
    Get full text

Professional experience

Senior Research Associate

Instituto de Biologia Experimental e Tecnológica - iBET

February 2017 - Present

Postdoctoral researcher

New University of Lisbon Faculty of Science and Technology

January 2015 - January 2017(2 years)

Postdoctoral researcher

New University of Lisbon Faculty of Science and Technology

July 2013 - November 2014(a year)

Research fellow

Universidade de Lisboa Faculdade de Medicina Veterinaria

January 2013 - June 2013(5 months)

Education

PhD

Faculdade de Ciências e Tecnologia - FCT-UNL

October 2006 - September 2012(6 years)

B.Sc.

Faculdade de Ciências da Universidade de Lisboa

September 2001 - July 2006(5 years)