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Florian Freudenberg

  • Dr. rer. nat.
  • Group leader
  • Universitätsklinikum Frankfurt
  • 8h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 216CitationsNumber of citations received by Florian's publications. Updated daily.

Research interests

NOS1APNOS1nNOSAMPA receptorsPDZ interactionNitric oxideNitrinergic systemGlutamatergic synapsePsychiatric disordersBrain plasticity

About

Our work group is interested in identifying the molecular mechanisms involved in the development of psychiatric disorders (particularly schizophrenia, affective disorders and their comorbidities). We mainly focus on synaptic mechanisms with a particular interest in proteins and protein interactions of the glutamatergic postsynapse. To investigate these mechanisms we employ a broad range of molecular, cytological and histological methods together with behavioral observations. One particular focus of our group is the selective transfer of genes into target brain areas using viral vectors (e.g. recombinant adeno-associated virus) and subsequent investigation of behavioral consequences. Moreover, we are making use of optogenetic stimulation in behaving animals to identify neural circuits involved in behaviors related to psychiatric disorders. Additionally, to further examine the underlying neurobiology and the role of our genes of interest in the pathogenesis of psychiatric disorders, we are also using genetically modified mouse strains with constitutive knockdown and inducible brain-region-specific overexpression of these genes combined with pharmacological manipulations targeting the protein interactions. Our current main interest revolves around neuronal nitric oxide synthase (NOS-I) and its interaction with proteins of the glutamatergic synapse. NOS1, the gene coding for NOS-I, and its adapter protein NOS1AP have repeatedly and consistently been associated with schizophrenia and integrity of NOS-I protein interaction has been suggested to be involved in the development of this disorder. We are investigating the importance of NOS-I/NOS1AP protein interaction using the above mentioned methods.

Groups

Co-authors (78)

Publications (5)

  • F193. Overexpression of NOS1AP in Dorsal Hippocampus and Medial Prefrontal Cortex Induces Schizophrenia-Related Phenotypic Changes

    • Candemir E
    • Fattakhov N
    • Li L
    • et al.
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  • Disrupting protein-protein interactions of neuronal nitric oxide synthase: implications in schizophrenia-related behaviours

    • Candemir E
    • Fattakhov N
    • Frerichs V
    • et al.
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  • The genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia: Further evidence and meta-analysis

    • Weber H
    • Klamer D
    • Freudenberg F
    • et al.
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  • GluA1 and its PDZ-interaction: A role in experience-dependent behavioral plasticity in the forced swim test

    • Freudenberg F
    • Marx V
    • Mack V
    • et al.
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  • Select overexpression of homer1a in dorsal hippocampus impairs spatial working memory.

    • Celikel T
    • Marx V
    • Freudenberg F
    • et al.
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Professional experience

Group leader

Universitätsklinikum Frankfurt

September 2014 - Present

Senior Scientist

Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie

October 2012 - August 2014(2 years)

Post-Doc

University of Southern California

August 2009 - August 2012(3 years)

PhD Student

Max Planck Institute for Medical Research

January 2006 - July 2009(4 years)

Education

MSc

Universität Bremen - University of Bremen

October 2000 - December 2005(5 years)