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Garry Buettner

  • PhD
  • University of Iowa
  • 65h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 19193CitationsNumber of citations received by Garry's publications. Updated daily.

Research interests

Quantitative BioenergeticsQuantitative Redox BiologyEPR SpectroscopyAscorbic Acid/Vitamin CFree Radical ChemistryRedox Biology

About

Dr. Buettner’s research focuses on the flow of electrons through chemical, biochemical, and biological systems and the consequences of changing the current in different biological circuits. In mitochondria electrons flow through a high flux circuit efficiently producing ATP, and H2O (respiration); however, some do not flow to dioxygen, rather just to NAD+ (glycolysis). Of special interest is the flow of electrons into the many low flux biochemical circuits that partially reduce dioxygen producing superoxide and hydrogen peroxide. Understanding quantitatively the elements of these circuits (e.g. antioxidants, redox enzymes, and proteins) and how they dictate the fundamental biology of cells and tissues and overall health of organisms is the primary goal. Using this information to improve human health is the ultimate reward.

Co-authors (462)

  • Thomas van 't Erve
  • Edward Ntim Gasu
  • Richard Naftalin

Publications (5)

  • Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy

    • Erudaitius D
    • Mantooth J
    • Huang A
    • et al.
    N/AReaders
    0Citations
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  • Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface

    • Wert K
    • Velez G
    • Cross M
    • et al.
    N/AReaders
    0Citations
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  • Pharmacologic ascorbate (P-AscH<sup>−</sup>) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma

    • Wilkes J
    • O’Leary B
    • Du J
    • et al.
    N/AReaders
    0Citations
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  • Superoxide dismutase mimetic GC4419 enhances the oxidation of pharmacological ascorbate and its anticancer effects in an H<inf>2</inf>O<inf>2</inf>-dependent manner

    • Heer C
    • Davis A
    • Riffe D
    • et al.
    N/AReaders
    2Citations
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  • Tumor cells have decreased ability to metabolize H<inf>2</inf>O<inf>2</inf>: Implications for pharmacological ascorbate in cancer therapy

    • Doskey C
    • Buranasudja V
    • Wagner B
    • et al.
    N/AReaders
    29Citations
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Professional experience

University of Iowa