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Giorgio Seano

  • PhD
  • Junior Group Leader
  • Institute Curie
  • 13h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 615CitationsNumber of citations received by Giorgio's publications. Updated daily.

Other IDs

Research interests

cell migrationvessel normalizationbreast cancerglioblastomaangiogenesis3D collective migration

About

I am currently a Postdoctoral Research Fellow at Massachusetts General Hospital and Harvard Medical School. My research interests are angiogenesis and cell migration, crucial biological processes in tumor biology. During my PhD training, I investigated the importance of integrin α6 in endothelial cell migration and tumor angiogenesis. I found that α6-blocking antibody inhibited tumor-induced formation of blood vessels and normalized the tumor vasculature (Cancer Res, 2009). This study opened new questions on an almost unknown step of sprouting angiogenesis: the process of vascular basement membrane breaching. Therefore, through further study with in vivo and ex vivo models, I recently provided the first evidence of a new sub-cellular structure – the endothelial podosome rosette – that controls blood vessel branching by drilling the vascular basement membrane around vessels to create openings for sprouting angiogenesis (Nat Cell Biol, 2014). This work has been highlighted in Nature Cell Biology as well as other high profile journals (e.g., Nature Reviews Cancer, Nature Review Cell Molecular Biology and Science Signalling). Moreover, my studies investigating vascular biology directed me to develop a model that allows us to study sprouting angiogenesis directly on human tissues. I designed and validated the first ex vivo human knock-down angiogenesis assay by coupling arterial rings from human umbilical cord with shRNA delivered by lentiviral transduction (Blood, 2013). This work was highlighted in the editorial section and on the journal cover of Blood.

Co-authors (147)

Publications (5)

  • A cerebellar window for intravital imaging of normal and disease states in mice

    • Askoxylakis V
    • Badeaux M
    • Roberge S
    • et al.
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    N/ACitations
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  • Vascular beds maintain pancreatic tumour explants for ex vivo drug screening

    • Bazou D
    • Maimon N
    • Gruionu G
    • et al.
    N/AReaders
    0Citations
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  • Human arterial ring angiogenesis assay

    • Seano G
    • Primo L
    N/AReaders
    0Citations
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  • Solid stress and elastic energy as measures of tumour mechanopathology

    • Nia H
    • Liu H
    • Seano G
    • et al.
    N/AReaders
    N/ACitations
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  • Three-dimensional chemotaxis-driven aggregation of tumor cells

    • Puliafito A
    • De Simone A
    • Seano G
    • et al.
    N/AReaders
    7Citations
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Professional experience

Junior Group Leader

Institut Curie

November 2017 - Present

Postdoc fellow

Massachusetts General Hospital

November 2013 - September 2017(4 years)

Research fellow

Harvard Medical School

October 2012 - September 2017(5 years)

PhD student

Departments of Clinical and Biological Sciences and Oncological Sciences, University of Torino, and Institute for Cancer Research and Treatment

February 2008 - November 2013(6 years)

Education history

PhD in Complex System in Life Science

University of Turin School of Medicine

January 2007 - December 2010(4 years)

Master degree in Medical Biotechnology

University of Turin School of Medicine

December 2003 - December 2006(3 years)

Bachelor’s Degree in Biotechnology

University of Turin School of Medicine

December 2000 - December 2003(3 years)