Medicinal chemistry and synthesis of biologically active compounds. Synthetic and theoretical chemistry of nitrogen containing heterocycles. Applied organometallic chemistry. Specialties: Hit to lead optimization and lead profiling. Flow chemistry.
Design and implementation of complex synthesis in order to build new chemical entities with proper pharmacological profile, applying the widest variety of chemical reactions, using classical batch and innovative continuous flow chemistry microreactor techniques.
Fragment Based Optimization of Metabotropic Glutamate Receptor 2 (mGluR2) Positive Allosteric Modulators in the Absence of Structural Information
Journal of Medicinal Chemistry (2018) acs.jmedchem.8b00161