Education, Training, and Professional Experience:
Hiroshi Yamazaki is a Professor of Laboratory of Drug Metabolism and Pharmacokinetics in Showa Pharmaceutical University, Tokyo, Japan since 2005. After receiving his BS and MS degrees from Gifu Pharmaceutical University and PhD in Pharmaceutical Sciences from Osaka University in Japan, he trained as a post-doctoral fellow at Vanderbilt University School of Medicine, Nashville, TN, USA in 1994. He was recruited as an Associate Professor of Kanazawa University from Osaka Prefectural Institute of Public Health in 1998 and moved to a post as Associate Professor of Hokkaido University Graduate School of Pharmaceutical Sciences in 2001.
Professor Yamazaki’s research has focused on polymorphic cytochrome P450 and flavin-containing monooxygenase, which are major catalysts involved in drug metabolism in toxicology and pharmacology in humans. He has authored over 360 publications (http://www.researcherid.com/rid/A-6081-2011) and is recognized as a ‘Highly Cited Researcher’ in Pharmacology 2001 by Thomson Reuters.
Selected papers in 2017:
1. Yamazaki, H., Suemizu, H., Mitsui, M., Shimizu, M., and Guengerich, F. P. Combining Chimeric mice with humanized liver, mass spectrometry, and physiologically-based pharmacokinetic modeling in toxicology. Chem. Res. Toxicol., 29, 1903-1911, 2016.
2. Uno, Y., Uehara, S., and Yamazaki, H. Utility of non-human primates in drug development: comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes. Biochem. Pharmacol., 121, 1-7, 2016.
3. Yamazaki, H. Differences in toxicological and pharmacological responses mediated by polymorphic cytochromes P450 and related drug-metabolizing enzymes. Chem. Res. Toxicol., 30, 53-60, 2017.
Selected book. Fifty Years of Cytochrome P450 Research, ed. Hiroshi Yamazaki, Springer, Tokyo, 2014
Professor Yamazaki has been the recipient of award from the Japanese Society for the Study of Xenobiotics (JSSX, 2014), young scientist awards from the Pharmaceutical Society of Japan (2000) and JSSX (2005). He was named a JSSX Fellow (2008).
Professor Yamazaki has been actively involved in professional organizations for several decades: Board Member of JSSX (2000-), Associate Editor (Drug Metabolism and Pharmacokinetics (DMPK), 2006-2009), Council member (2010-2017), Editor-in-Chief of DMPK (2014-2017), and President-elect (2016-2017). He served as a Councilor of ISSX from 2011 – 2014. Professor Yamazaki also serves as an Editorial Advisory Board member for Biochem. Pharmacol., Brit. J. Clin. Pharmacol., and Chem. Res. Toxicol. Professor Yamazaki is on the Meeting Organizing Committee for 19th North American ISSX/29th JSSX Meeting 2014 and is the leading organizer of 19th International Conference on Cytochrome P450, in Tokyo, Japan, 2015.
Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate
Importance of cynomolgus monkeys in development of monoclonal antibody drugs