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James C Keith, Jr

  • DVM, PHD/Chief Scientific Officer/Emstopa, Ltd
  • 34h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 5190CitationsNumber of citations received by James C's publications. Updated daily.


SUMMARY: Research Pharmacologist with 35 years of experience in comparative medicine, animal models of human disease, drug discovery, preclinical research and drug development. SPECIALITIES: Pharmacology Research, Comparative Medicine, Animal Models of Human Disease, Hypertension of Pregnancy, Vascular Biology and Inflammation, Histology and Electron microscopy, Veterinary Medicine WORK EXPERIENCE: Dr. Keith most recently was Founder and Senior Consultant at Keith Pharmacology Research Group, a consulting company focused on providing advice to the pharmaceutical industry on Comparative Medicine-Animal Models of Human Disease, as well as preclinical study design, review of experimental data, analysis and documentation of animal model studies, scientific report preparation, and manuscript preparation and editing. He is author or co-author of over 145 peer-reviewed papers and book chapters, an invited reviewer for multiple national and international scientific journals, and an inventor or co-inventor on 31 issued US and International patents. Dr. Keith worked at Genetics Institute / Wyeth Research / Pfizer, and achieved the title of Distinguished Research Fellow (2006 – 2011), after starting his career with them as a Senior Principal Scientist and Lab Head of the Animal Models Laboratory in Preclinical Research in 1993. His laboratories conducted animal model studies defining biologic activities, biomarkers of efficacy and safety, and minimum effective doses of cardiovascular, inflammatory disease drug candidate molecules, recombinant human cytokines, and recombinant human therapeutic proteins for hemophilia. The pharmacology research and development contributed to the approval of Neumega, BeneFIX, ReFacto (Europe), ReFacto (US), and Xyntha. Prior to entering the pharmaceutical industry, Dr. Keith served 11 years as an Assistant and Associate Professor of Veterinary Medicine at the Virginia-Maryland Regional College of Veterinary Medicine. Atherosclerosis research continued and the new area of interest concerning the pathophysiology of preeclampsia emerged. Dr. Keith is a member of numerous professional organizations, including the American Heart Association, the American Physiological Society, the American Veterinary Medical Association, the Shock Society, the New York Academy of Sciences, the Royal Society of Medicine (London)-Fellow, and the International Society for the Study of Hypertension in Pregnancy.

Recent publications

  • Atherosclerotic plaque tissue: Noninvasive quantitative assessment of characteristics with software-aided measurements from conventional CT angiography

    • Sheahan M
    • Ma X
    • Paik D
    • et al.
  • Interleukin-11. Biological activity and clinical studies

    • Dorner A
    • Goldman S
    • Keith Jr. J

Co-authors (394)

  • Maya Gagolashvili

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