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Jason Gerstner

  • PhD
  • Assistant Research Professor
  • Washington State University - Spokane
  • 12h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 585CitationsNumber of citations received by Jason's publications. Updated daily.

Other IDs

Research interests

neurobiology of learning and memorysynaptic plasticitygeneticscellular and molecular biologysleep and circadian rhythms

About

I am currently working in the College of Medical Sciences at Washington State University. Previously I discovered and characterized the unique time-of-day cycling of the brain-type fatty-acid binding protein (Fabp7) in mammalian brain (Gerstner et al., 2006; Gerstner et al., 2008). What made these findings novel was that prior to these observations, it was not known whether oscillations in specific transcripts of cycling genes occur in phase brain-wide, since canonical 'clock' genes cycle out of phase in extra-SCN areas. Given the importance of cycling molecules in memory formation (Gerstner and Yin, 2010), I then cloned and characterized the Fabp7 homologue dFabp in the fruit fly Drosophila melanogaster, and made transgenic flies that over-express the murine Fabp7 or dFabp, in order to test whether changes in Fabp levels confer sleep and memory phenotypes (Gerstner et al., 2011a; Gerstner et al., 2011b). I then explored the subcellular localization of Fabp7 in the mouse model, where relative levels of Fabp7 mRNA concentration oscillate in the perisynaptic process compartment over the light-dark cycle in astroglia (Gerstner et al., 2012). Currently I am assessing the circadian rhythm, sleep, and homeostatic response to sleep deprivation in the Fabp7 KO mouse model, and the relationship of Fabp expression with sleep and memory to aging related disease in Drosophila. Specialties sleep and circadian rhythms, cellular and molecular biology, genetics, synaptic plasticity, neurobiology of learning and memory

Co-authors (62)

  • Dawn Loh
  • Arun Handa

Recent publications

  • Alzheimer’s disease and sleep–wake disturbances: Amyloid, astrocytes, and animal models

    • Vanderheyden W
    • Lim M
    • Musiek E
    • et al.
    N/AReaders
    1Citations
    Get full text
  • Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7

    • Gerstner J
    • Perron I
    • Riedy S
    • et al.
    N/AReaders
    6Citations
    Get full text

Professional experience

Assistant Research Professor

Washington State University - Spokane - Washington State University at Spokane

June 2014 - Present

Postdoctoral Fellow

University of Pennsylvania

July 2010 - June 2014(4 years)

Assistant Scientist

Department of Genetics, University of Wisconsin-Madison

September 2008 - July 2010(2 years)

Education

PhD

University of Wisconsin-Madison

June 2003 - December 2008(6 years)