Jonathan Shillingford Ph.D.

Scientific Knowledge Manager

Intervention Insights

Location
Grand Rapids, Michigan, United States
Discipline
Medicine
Interests
Personalized medicine, molecular and biological drug targets, oncology
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About

I have spent most of my life in the realm of scientific research thanks in large part to the enthusiasm of a few teachers I had back in school. I pursued my higher education in the UK where I obtained an undergraduate degree (B.Sc.) in cell and molecular biology and a graduate degree (Ph.D.) in biomolecular physiology. From there, I moved across the pond to the NIH (Bethesda, MD) where I was engaged in a postdoctoral position in the field of mammary gland biology with emphasis on the use of the mouse as a model system. Following my postdoc, I moved westwards to Cleveland, OH and then Santa Barbara, CA where I studied polycystic kidney disease (PKD) with emphasis on targeting aberrant molecular pathways to aid in the informed design of therapeutic drug approaches. I recently moved back east to take a senior scientist position with a personalized medicine company in Grand Rapids, MI where I am involved in leveraging, curating, documenting, and building their scientific knowledge base for use in their OncInsights report generation that helps inform physicians of potential targeted therapies for individual cancer patients.
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Publications

  • Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.

    Cases S, Zhou P, Shillingford J, Wiseman B, Fish J, Angle C et al.

    Development Cambridge England (2004)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Experimental mouse genetics-- answering fundamental questions about mammary gland biology.

    Shillingford J, Hennighausen L

    Trends in endocrinology and metabolism TEM (2001)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease.

    Olsan E, Mukherjee S, Wulkersdorfer B, Shillingford J, Giovannone A, Todorov G et al.

    Proceedings of the National Academy of Sciences of the United States of America (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Function of the spalt/spalt-related gene complex in positioning the veins in the Drosophila wing.

    Walton K, Wagner K, Rucker E, Shillingford J, Miyoshi K, Hennighausen L

    Mechanisms of Development (2000)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Acute Myeloid Leukemia-Associated Mkl1 (Mrtf-a) Is a Key Regulator of Mammary Gland Function

    Sun Y, Boyd K, Xu W, Ma J, Jackson C, Fu A et al.

    Molecular and Cellular Biology (2006)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis.

    Shillingford J, Miyoshi K, Flagella M, Shull G, Hennighausen L

    Molecular endocrinology Baltimore Md (2002)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Image Segmentation, Registration and Visualization of Serial MR Images for Therapeutic Assessment of Polycystic Kidney Disease in Transgenic Mice.

    Fei B, Flask C, Wang H, Pi A, Wilson D, Shillingford J et al.

    Conference Proceedings of the International Conference of IEEE Engineering in Medicine and Biology Society (2005)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.

    Long W, Wagner K, Lloyd K, Binart N, Shillingford J, Hennighausen L et al.

    Development Cambridge England (2003)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Polycystin-1 regulates STAT activity by a dual mechanism.

    Talbot J, Shillingford J, Vasanth S, Doerr N, Mukherjee S, Kinter M et al.

    Proceedings of the National Academy of Sciences of the United States of America (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium.

    Shillingford J, Miyoshi K, Robinson G, Grimm S, Rosen J, Neubauer H et al.

    Molecular endocrinology Baltimore Md (2002)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation.

    Bierie B, Nozawa M, Renou J, Shillingford J, Morgan F, Oka T et al.

    Oncogene (2003)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.

    Miyoshi K, Shillingford J, Le Provost F, Gounari F, Bronson R, Von Boehmer H et al.

    Proceedings of the National Academy of Sciences of the United States of America (2002)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium.

    Miyoshi K, Shillingford J, Smith G, Grimm S, Wagner K, Oka T et al.

    The Journal of Cell Biology (2001)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

    Shillingford J, Piontek K, Germino G, Weimbs T

    Journal of The American Society Of Nephrology (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

    Shillingford J, Murcia N, Larson C, Low S, Hedgepeth R, Brown N et al.

    Proceedings of the National Academy of Sciences of the United States of America (2006)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Professional experience

Scientific Knowledge Manager

Intervention Insights

January 2012 - Present

Project Scientist

UC Santa Barbara

June 2005 - December 2011 (6 years 6 months)

Education history

University of Wales, Aberystwyth

Ph.D.

September 1993 - November 1997 (4 years 2 months)

University of Wolverhampton

B.Sc. (hons)

September 1990 - June 1993 (2 years 9 months)