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Julien Marcoux

  • CNRS Research Associate
  • Institute of Pharmacology and Structural Biology
  • 10PublicationsNumber of items in Julien's My Publications folder on Mendeley.

Research interests

native MScross-linkingion mobilityhydrogen deuterium exchangeproteasomestructural biologymass spectrometry

About

My research interests are focused towards using mass spectrometry as a tool for studying soluble and membrane associated protein assemblies. During my time as a Ph.D. student I have applied mass spectrometry to unravel the structural mechanism of activation of the NADPH oxidase. The project also gave me the opportunity to gain experimental experience in various biophysical techniques as well as in molecular biology, protein expression and purification. I expanded and developed these skills during my two postdoctoral positions in Oxford and Strasbourg, by applying them to significantly larger soluble complexes and membrane proteins. I have had the fortunate opportunity to present my research at both national and international conferences and possess publishable writing skills. I recently obtained a CNRS Research Associate position at the Institute of Pharmacology and Structural Biology in Toulouse, where I will develop structural MS-based methods for the analysis of supramolecular complexes.

Following (1)

Publications (5)

  • Conformational changes in p47phox upon activation highlighted by mass spectrometry coupled to hydrogen/deuterium exchange and limited proteolysis

    • Marcoux J
    • Man P
    • Castellan M
    • et al.
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  • Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump

    • Marcoux J
    • Wang S
    • Politis A
    • et al.
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    N/ACitations
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  • Twenty years of gas phase structural biology

    • Marcoux J
    • Robinson C
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  • NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

    • Jaquet V
    • Marcoux J
    • Forest E
    • et al.
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    N/ACitations
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  • Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

    • Patrizia Mangione P
    • Porcari R
    • Gillmore J
    • et al.
    N/AReaders
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Professional experience

CNRS Research Associate

Institute of Pharmacology and Structural Biology

February 2015 - Present

Post-Doc

Hubert Curien Multidisciplinary Institute Department of Analytical Sciences

February 2014 - January 2015(a year)

Post-Doc

Department of Chemistry, University of Oxford

March 2011 - January 2014(3 years)

Research Associate

PolyTherics Ltd

August 2010 - January 2011(5 months)

PhD

Institute of Structural Biology, Grenoble, France

September 2006 - April 2010(4 years)