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Manuela Pastore

    • 1PublicationsNumber of items in Manuela's My Publications folder on Mendeley.
    • 1Followers

    About

    My name is Manuela Pastore and I am an Italian biologist. After my BSc in Biosanitary Biology which I obtained from the University of Palermo, I moved to the prestigious University of Pisa where I obtained a Master's degree in Biology applied to Bio-Medical Sciences (Physiopathology Curriculum). I had the opportunity to study Genetics, Molecular genetics, Cytogenetics, Human genetics, Pharmacogenetics, Statistics and many other topics. During the years of University I performed studies on cell cultures and chemical, hematological, immunologic, histopathological, cytopathological, microscopic, and bacteriological diagnostic analyses on body fluids such as blood, urine, sputum, stool, cerebrospinal fluid, peritoneal fluid, pericardial fluid, and synovial fluid, as well as other specimens, in Villa Sofia Hospital, Palermo, Italy at the Department of Clinical Pathology. From 2014-2015 I had the opportunity to do a traineeship at the DKFZ of Heidelberg at the Genomic Epidemiology group where I wrote my master’s thesis titled “Genetic variability of the p16 locus and pancreatic cancer susceptibility” and also submitted four articles: one published, the second one in publication and the others in preparation.. At the DKFZ, I was involved in the study of the genetic susceptibility to pancreatic disorders, with particular focus on pancreatic cancer. I participated in several projects. My main focus was on the role of germline genetic variability at the CDKN2A locus, in relation to exocrine pancreatic cancers, neuroendocrine pancreatic tumors and chronic pancreatitis. I performed a replication and validation of associations between polymorphisms reported in the literature to be associated with pancreatic exocrine cancer in pancreatic neuroendocrine tumors. I further analyzed polymorphisms reported to be associated with risk of chronic pancreatitis to verify if they are associated with risk of pancreatic cancer as well. Tasks carried out by me included setup of study samples and genotyping assays, large-scale genotyping, quality control of genotyping data, statistical analysis. During that period of training I learnt all different phases of a typical case-control epidemiological association, with particular emphasis on the investigation of genetic polymorphisms in relation to disease risk. From the point of view of labwork, I learnt management of a large sample set and genotyping with TaqMan and KASPar technology. Concerning data analysis, I learnt the basics of checking quality control of a large dataset, statistical analysis and interpretation of results. During this time, I showed total dedication to the project and willingness to learn by taking part in advanced learning English language courses organized by the DKFZ as well as the ‘Tell Me Something I Don’t Know About Cancer’ Journal Club organised by the Department of Molecular Epidemiology and Genomic Epidemiology group.

    Followers (1)

    • parvez khan

      parvez khanHazara University

    Following (2)

    Publications (1)

    • Functional single nucleotide polymorphisms within the cyclin- dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk

      • Campa D
      • Pastore M
      • Gentiluomo M
      • et al.
      N/AReaders
      N/ACitations

    Professional experience

    Traineeship

    Deutsches Krebsforschungszentrum

    September 2014 - March 2015(6 months)

    Education history

    MSc in Biology applied to Bio-Medical Sciences (Physiopathology Curriculum)

    Universita degli Studi di Pisa

    January 2010 - January 2015(5 years)