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Michael Dean

  • PhD
  • Chief, Laboratory of Translational Genomics
  • National Cancer Institute
  • 89h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 45596CitationsNumber of citations received by Michael's publications. Updated daily.

Research interests

Cancer GenomicsCancerHuman Genetics


We are broadly interested in inherited (germline) genetic variation, somatic mutations in tumors, and the combined effect of both on cancer risk, progression, and response to therapy. Our group participated in cloning genes (PTCH, VHL) involved in inherited cancers; characterized common variants associated with cancer; and sequenced the genomes of tumors to identify genes commonly altered. As Chief of LTG, I am expanding our work on unlocking the mechanisms through which genetic alterations affect cancer risk. By evaluating the genetic factors of tumor as well as host, we are determining new biomarkers for early detection and treatment. We also continues his investigations into the genetic components of cancer health disparities in the U.S. and in Latin America.

Co-authors (2337)

  • Silvia Archila Jiménez
  • Hanjie Wu
  • João Delou
  • WANG Changzheng
  • Jérôme Robert
  • Felix Simon Ruben Picard


Human Mutation

Editorial Board

2008 - Present

Publications (5)

  • The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis

    • Mirabello L
    • Clarke M
    • Nelson C
    • et al.
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  • TET2 binds the androgen receptor and loss is associated with prostate cancer

    • Nickerson M
    • Das S
    • Im K
    • et al.
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  • Amyloid-associated depression and ApoE4 allele: Longitudinal follow-up for the development of Alzheimer's disease

    • Qiu W
    • Zhu H
    • Dean M
    • et al.
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  • Characterization of large structural genetic mosaicism in human autosomes

    • Machiela M
    • Zhou W
    • Sampson J
    • et al.
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  • Lymphoid neoplasia: A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults

    • Perez-Andreu V
    • Roberts K
    • Xu H
    • et al.
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Professional experience

Chief, Laboratory of Translational Genomics

National Cancer Institute

June 2015 - Present

Education history


Boston University Department of Biochemistry

August 1979 - January 1983(3 years)