Skip to content

Michael Hoffman

  • PhD
  • Assistant Professor
  • University of Toronto Department of Medical Biophysics
  • 0ReadersNumber of instances of Michael's publications in Mendeley libraries. Updated daily.
  • 15PublicationsNumber of items in this person’s My Publications folder on Mendeley.

Research interests

chromatinmachine learningfunctional genomics


I develop machine learning methods for functional genomics. I am responsible for Segway, a dynamic Bayesian network method for simultaneously segmenting and clustering multiple tracks of data from ChIP-seq or DNase-seq experiments.

Followers (18)

  • Ilya Klabukov

    Ilya KlabukovI M Sechenov First Moscow State Medical University

  • Roberto Alvarez

    Roberto Alvarez

  • Arnaud Ceol

    Arnaud CeolIstituto Italiano di Tecnologia

  • Yuchun Guo

    Yuchun GuoMassachusetts Institute of Technology



  • He Zhu

    He Zhu

Explore network

Following (6)

Publications (15)

Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell type-specific expression

  • Libbrecht M
  • Ay F
  • Hoffman M
Genome Research (2015)
  • n/a


  • n/a


Full text

Statistical Inference , Learning and Models in Big Data

  • Franke B
  • Plante J
  • Roscher R
  • n/a


  • n/a


Comparative analysis of metazoan chromatin organization

  • Ho J
  • Jung Y
  • Liu T
Nature (2014)
  • n/a


  • n/a


Full text

Integrative annotation of chromatin elements from ENCODE data.

  • Hoffman M
  • Ernst J
  • Wilder S
Nucleic Acids Research (2013)
  • n/a


  • n/a


Full text

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.

  • Landt S
  • Marinov G
  • Kundaje A
Genome Research (2012)
  • n/a


  • n/a


Full text

Professional experience

Assistant Professor

Department of Medical Biophysics, University of Toronto

April 2014 - Present


Princess Margaret Cancer Centre

November 2013 - Present

Senior Fellow

Department of Genome Sciences, University of Washington

September 2008 - October 2013(5 years)

Predoctoral Fellow

European Bioinformatics Institute

October 2003 - July 2008(5 years)

Research Assistant

Department of Chemistry and Biochemistry, University of Texas at Austin

May 1999 - September 2003(4 years)

Education history

Doctor of Philosophy

Trinity College, University of Cambridge

October 2003 - July 2008(5 years)

Bachelor of Science, Biochemistry; Bachelor of Arts, Plan II Honors Liberal Arts

The University of Texas at Austin

August 1998 - May 2003(5 years)