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Michael Hoffman

  • PhD
  • Assistant Professor
  • University of Toronto Department of Medical Biophysics
  • 0ReadersNumber of instances of Michael's publications in Mendeley libraries. Updated daily.
  • 15PublicationsNumber of items in this person’s My Publications folder on Mendeley.

Research interests

chromatinmachine learningfunctional genomics


I develop machine learning methods for functional genomics. I am responsible for Segway, a dynamic Bayesian network method for simultaneously segmenting and clustering multiple tracks of data from ChIP-seq or DNase-seq experiments.

Followers (19)

  • James Lawlor

    James LawlorHudsonAlpha Institute for Biotechnology

  • Ilya Klabukov

    Ilya KlabukovI M Sechenov First Moscow State Medical University

  • Roberto Alvarez

    Roberto Alvarez

  • Arnaud Ceol

    Arnaud CeolIstituto Italiano di Tecnologia

  • Yuchun Guo

    Yuchun GuoMassachusetts Institute of Technology



Explore network

Following (6)

Publications (15)

Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell type-specific expression

  • Libbrecht M
  • Ay F
  • Hoffman M
Genome Research (2015)
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Statistical Inference , Learning and Models in Big Data

  • Franke B
  • Plante J
  • Roscher R
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Comparative analysis of metazoan chromatin organization

  • Ho J
  • Jung Y
  • Liu T
Nature (2014)
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Integrative annotation of chromatin elements from ENCODE data.

  • Hoffman M
  • Ernst J
  • Wilder S
Nucleic Acids Research (2013)
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ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.

  • Landt S
  • Marinov G
  • Kundaje A
Genome Research (2012)
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Professional experience

Assistant Professor

Department of Medical Biophysics, University of Toronto

April 2014 - Present


Princess Margaret Cancer Centre

November 2013 - Present

Senior Fellow

Department of Genome Sciences, University of Washington

September 2008 - October 2013(5 years)

Predoctoral Fellow

European Bioinformatics Institute

October 2003 - July 2008(5 years)

Research Assistant

Department of Chemistry and Biochemistry, University of Texas at Austin

May 1999 - September 2003(4 years)

Education history

Doctor of Philosophy

Trinity College, University of Cambridge

October 2003 - July 2008(5 years)

Bachelor of Science, Biochemistry; Bachelor of Arts, Plan II Honors Liberal Arts

The University of Texas at Austin

August 1998 - May 2003(5 years)