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Michael Hoffman

  • PhD
  • Assistant Professor
  • University of Toronto Department of Medical Biophysics
  • 15PublicationsNumber of items in Michael's My Publications folder on Mendeley.
  • 19Followers

Research interests

chromatinmachine learningfunctional genomics


I develop machine learning methods for functional genomics. I am responsible for Segway, a dynamic Bayesian network method for simultaneously segmenting and clustering multiple tracks of data from ChIP-seq or DNase-seq experiments.

Followers (19)

Explore network

Following (6)

Publications (5)

  • Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell type-specific expression

    • Libbrecht M
    • Ay F
    • Hoffman M
    • et al.
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  • Statistical Inference , Learning and Models in Big Data

    • Franke B
    • Plante J
    • Roscher R
    • et al.
  • Comparative analysis of metazoan chromatin organization

    • Ho J
    • Jung Y
    • Liu T
    • et al.
    Get full text
  • Integrative annotation of chromatin elements from ENCODE data.

    • Hoffman M
    • Ernst J
    • Wilder S
    • et al.
    Get full text
  • ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.

    • Landt S
    • Marinov G
    • Kundaje A
    • et al.
    Get full text

Professional experience

Assistant Professor

Department of Medical Biophysics, University of Toronto

April 2014 - Present


Princess Margaret Cancer Centre

November 2013 - Present

Senior Fellow

Department of Genome Sciences, University of Washington

September 2008 - October 2013(5 years)

Predoctoral Fellow

European Bioinformatics Institute

October 2003 - July 2008(5 years)

Research Assistant

Department of Chemistry and Biochemistry, University of Texas at Austin

May 1999 - September 2003(4 years)


Doctor of Philosophy

Trinity College, University of Cambridge

October 2003 - July 2008(5 years)

Bachelor of Science, Biochemistry; Bachelor of Arts, Plan II Honors Liberal Arts

The University of Texas at Austin

August 1998 - May 2003(5 years)