Michael Jeltsch Dr.

Group leader & Academy Research Fellow

Helsingin yliopisto - University of Helsinki

Location
Helsinki, Finland
Discipline
Biological Sciences
Interests
(Lymph)angiogenesis, Protein production and purification
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  • 6 Followers

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About

2002 PhD (Biochemistry), University of Helsinki, Finland
1997 MSc (Biochemistry), University of Helsinki, Finland
1992 BSc ("Vordiplom", Biochemie/Molekularbiologie), University of Hamburg, Germany
1989 Allgemeine Hochschulreife, Gymnasium An der Stenner, Iserlohn, Germany
July 28, 1969 Born in Hemer/NW, Germany
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Publications

  • Die genetischen Ursachen des primären Lymphödems

    Mattonet K, Wilting J, Jeltsch M

    Erkrankungen des Lymphgefäßsystems (2015)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Receptor Tyrosine Kinase-Mediated Angiogenesis

    Jeltsch M, Leppanen V, Saharinen P, Alitalo K

    Cold Spring Harbor Perspectives in Biology (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Signalling via VEGFR-3 is sufficient for lymphangiogenesis in transgenic mice.

    Jussila L, Veikkola T, Jeltsch M, Thurston G, McDonald D, Achen M et al.

    Clinical Cancer Research (2001)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Critical Role of VEGF-C/VEGFR-3 Signaling in Innate and Adaptive Immune Responses in Experimental Obliterative Bronchiolitis

    Krebs R, Tikkanen J, Ropponen J, Jeltsch M, Jokinen J, Yla-Herttuala S et al.

    American Journal of Pathology (2012)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D. Teil 2: Die Rolle von VEGF-C und VEGF-D bei Krankheiten des Lymphgefäßsystems. TT - The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 2: The role of VEGF-C and VEGF-D in deseases of the l

    Krebs R, Jeltsch M

    Lymphologie in Forschung und Praxis (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

    Leppanen V, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N et al.

    Blood (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 2: The role of VEGF-C and VEGF-D in lymphatic system diseases

    Krebs R, Lackner M, Jeltsch M

    Vasomed (2014)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Structural determinants of growth factor binding and specificity by VEGF receptor 2

    Leppanen V, Prota A, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T et al.

    Proceedings of the National Academy of Sciences of the United States of America (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • VEGF-C adenovirus gene transfer reduces intima formation in rabbits

    Hiltunen M, Laitinen M, Turunen M, Jeltsch M, Hartikainen J, Rissanen T et al.

    Atherosclerosis (2000)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor-1 Ligands

    Anisimov A, Leppanen V, Tvorogov D, Zarkada G, Jeltsch M, Holopainen T et al.

    Science Signaling (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

    Leppanen V, Tvorogov D, Kisko K, Prota A, Jeltsch M, Anisimov A et al.

    Proceedings of the National Academy of Sciences of the United States of America (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

    Anisimov A, Tvorogov D, Alitalo A, Leppanen V, An Y, Han E et al.

    Circulation (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • VEGF-C/VEGFR-3 Signaling Regulates Inflammatory Response in Development of Obliterative Airway Disease

    Krebs R, Tikkanen J, Ropponen J, Jeltsch M, Jokinen J, Yla-Herttuala S et al.

    Journal of Heart and Lung Transplantation (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 1: Fundamentals and embryonic development

    Krebs R, Jeltsch M

    Vasomed (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3-Mediated Vascular Endothelial Growth Factor-C Activation

    Jeltsch M, Jha S, Tvorogov D, Anisimov A, Leppanen V, Holopainen T et al.

    Circulation (2014)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Substrate efflux propensity is the key determinant of iPLA-β-mediated glycerophospholipid hydrolysis

    Batchu K, Hokynar K, Jeltsch M, Mattonet K, Somerharju P

    Journal of Biological Chemistry (2015)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D. Teil 1: Grundlagen und Embryonalentwicklung. TT - The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 1: Basic principles and embryonic development.

    Krebs R, Jeltsch M

    Lymphologie in Forschung und Praxis (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.

    Villefranc J, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore J et al.

    Development Cambridge England (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle.

    Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen V et al.

    Circulation research (2009)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.

    Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M et al.

    Genes & development (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation.

    Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J et al.

    Circulation (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis.

    Albrecht I, Kopfstein L, Strittmatter K, Schomber T, Falkevall A, Hagberg C et al.

    PloS one (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Effective Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor Dimerization.

    Tvorogov D, Anisimov A, Zheng W, Leppänen V, Tammela T, Laurinavicius S et al.

    Cancer cell (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.

    Veikkola T, Lohela M, Ikenberg K, Mäkinen T, Korff T, Saaristo A et al.

    The FASEB Journal (2003)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.

    Veikkola T, Jussila L, Makinen T, Karpanen T, Jeltsch M, Petrova T et al.

    The EMBO Journal (2001)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes

    Saaristo A, Veikkola T, Enholm B, Hytönen M, Arola J, Pajusola K et al.

    The FASEB Journal (2002)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity

    Pepper M, Mandriota S, Jeltsch M, Kumar V, Alitalo K

    Journal of Cellular Physiology (1998)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

    Olofsson B, Korpelainen E, Pepper M, Mandriota S, Aase K, Kumar V et al.

    Proceedings of the National Academy of Sciences (1998)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Current biology of VEGF-B and VEGF-C.

    Olofsson B, Jeltsch M, Eriksson U, Alitalo K

    Current Opinion in Biotechnology (1999)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis.

    Mandriota S, Jussila L, Jeltsch M, Compagni A, Baetens D, Prevo R et al.

    The EMBO journal (2001)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane

    Oh S, Jeltsch M, Birkenhager R, Mccarthy J, Weich H, Christ B et al.

    Developmental Biology (1997)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.

    Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K et al.

    Arteriosclerosis, thrombosis, and vascular biology (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development

    Kukk E, Lymboussaki A, Taira S, Kaipainen A, Jeltsch M, Joukov V et al.

    Development (1996)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Dual Role of Vascular Endothelial Growth Factor in Experimental Obliterative Bronchiolitis

    Krebs R, Tikkanen J, Nykänen A, Wood J, Jeltsch M, Ylä-Herttuala S et al.

    American Journal of Respiratory and Critical Care Medicine (2005)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein

    Keskitalo S, Tammela T, Lyytikka J, Karpanen T, Jeltsch M, Markkanen J et al.

    Circulation Research (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Functional interaction of VEGF-C and VEGF-D with neuropilin receptors

    Karpanen T, Heckman C, Keskitalo S, Jeltsch M, Ollila H, Neufeld G et al.

    The FASEB Journal (2006)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Hyperplasia of lymphatic vessels in VEGF-C transgenic mice

    Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H et al.

    Science (1997)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy

    Karpanen T, Bry M, Ollila H, Seppa T, Liimatta E, Leskinen H et al.

    Circulation Research (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

    Karkkainen M, Haiko P, Sainio K, Partanen J, Taipale J, Petrova T et al.

    Nature Immunology (2004)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular Endothelial Growth Factors VEGF-B and VEGF-C

    Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V et al.

    Journal of Cellular Physiology (1997)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Proteolytic processing regulates receptor specificity and activity of VEGF-C

    Joukov V, Sorsa T, Kumar V, Jeltsch M, Claesson-Welsh L, Cao Y et al.

    The EMBO Journal (1997)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • VEGFR-3 Ligands and Lymphangiogenesis

    Jeltsch M

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Functional Analysis of VEGF-B and VEGF-C

    Jeltsch M

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • VEGF Receptors

    Alitalo K, Jeltsch M

    Sigma-RBI Handbook of Receptor Classification and Signal Transduction (2006)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular Endothelial Growth Factor (VEGF)/VEGF-C Mosaic Molecules Reveal Specificity Determinants and Feature Novel Receptor Binding Patterns (Supplemental Data #3)

    Jeltsch M, Karpanen T, Strandin T, Aho K, Lankinen H, Alitalo K

    Journal of Biological Chemistry (2006)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular Endothelial Growth Factor (VEGF)/VEGF-C Mosaic Molecules Reveal Specificity Determinants and Feature Novel Receptor Binding Patterns

    Jeltsch M, Karpanen T, Strandin T, Aho K, Lankinen H, Alitalo K

    Journal of Biological Chemistry (2006)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Genesis and pathogenesis of lymphatic vessels

    Jeltsch M, Tammela T, Alitalo K, Wilting J

    Cell and Tissue Research (2003)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta

    Hiltunen M, Laitinen M, Turunen M, Jeltsch M, Hartikainen J, Rissanen T et al.

    Circulation (2000)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular Endothelial Cell Growth Factor Receptor 3–Mediated Activation of Lymphatic Endothelium Is Crucial for Tumor Cell Entry and Spread via Lymphatic Vessels

    He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S et al.

    Cancer Research (2005)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • VEGF guides angiogenic sprouting utilizing endothelial tip cell fillopodia

    Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A et al.

    The Journal of Cell Biology (2003)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin

    Enholm B, Karpanen T, Jeltsch M, Kubo H, Stenback F, Prevo R et al.

    Circulation Research (2001)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Genomic Organization of Human and Mouse Genes for Vascular Endothelial Growth Factor C

    Chilov D, Kukk E, Taira S, Jeltsch M, Kaukonen J, Palotie A et al.

    The Journal of Biological Chemistry (1997)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation

    Baluk P, Tammela T, Ator E, Lyubynska N, Achen M, Hicklin D et al.

    Journal of Clinical Investigation (2005)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

    Achen M, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks A et al.

    Proceedings of the National Academy of Sciences (1998)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins

    Tammela T, He Y, Lyytikkä J, Jeltsch M, Markkanen J, Pajusola K et al.

    Circulation Research (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The Tyrosine Kinase Inhibitor Cediranib Blocks Ligand-Induced Vascular Endothelial Growth Factor Receptor-3 Activity and Lymphangiogenesis

    Heckman C, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S et al.

    Cancer Research (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Professional experience

Group leader & Academy Research Fellow

Helsingin yliopisto - University of Helsinki

September 2013 - Present

Postdoctoral Fellow

Wihuri Research Institute

January 2013 - August 2013 (7 months)

graduate student, postgraduate student, postdoc

Molecular/Cancer Biology Lab, University of Helsinki

May 1996 - August 2013 (17 years 3 months)

Researcher

Circadian Technologies via Vegenics Ltd. via Licentia Ltd.

February 2007 - December 2011 (4 years 10 months)

Researcher

Lymphatix Ltd. (now Ark Therapeutics) via Licentia Ltd.

April 2006 - January 2007 (9 months)

Studentische Hilfskraft

Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg

August 1993 - July 1994 (11 months)