1991 Degree in Biology from Faculdade de Ciências da Universidade de Lisboa (FC/UL) 1995 Master of Science in Biotechnology (Biochemical Engineering) from Instituto Superior Técnico da Universidade Técnica de Lisboa (IST/UTL)
2001 PhD in Biology (Microbial Genetics) from Faculdade de Ciências da Universidade de Lisboa
2012 Habilitation in Biomedical Sciences (Speciality Microbiology) - (Agregação em Ciências Biomédicas – Especialidade Microbiologia) from Instituto de Higiene e Medicina Tropical/ Universidade Nova de Lisboa.
Area of scientific activity: Scientific activity devoted to the early diagnosis of active or latent tuberculosis (TB) infections as well as the development of new therapeutical approaches to deal with MDRTB and with other drug resistant bacterial infections. Also interested in molecular biology of mycobacteria and immunology of TB. Executive Member of the Scientific Council of the Masters in Medical Microbiology of the UNL. As Deputy-Director of the TB Laboratory of the IHMT (since 2001) has contributed to the resolution of the pulmonary TB problem of Lisbon by the generation of complete reports within a period of 15 to 20 days for 10 Hospitals of the TB Task Force of Lisbon. Over 120 studies published in peer review national and international journals in mycobacteriology, bacteriology, resistance to antibiotics, microbial genetics, molecular epidemiology and immunology.
Domain of specializations: Medical Microbiology, bacteriology, mycobacteriology, laboratory diagnosis of mycobacterial infections, molecular biology and genetics of Mycobacterium sp. Tuberculosis. Molecular typing of multidrug-resistant Mycobacterium tuberculosis. Mechanisms and strategies to circumvent drug resistance in mycobacteria, composition of the mycobacterial cell wall/envelope in relation to drug resistance, new antibiotics, antibiotic uptake, efflux-pumps, drug targeting and molecular vectorisation, nanotechnology, flow-cytometry. Present research interests: Research in tuberculosis and antibiotic resistant infections in support for alternative therapies of incurable diseases such as multidrug resistant tuberculosis and methicillin-vancomycin resistant staphylococcal infections. Immunology of tuberculosis. Strong interests in assisting Portuguese speaking countries of Africa in combating tuberculosis. Expertise in the laboratory diagnosis of tuberculosis infections.
Research funding : Principal Investigator/Team Leader of 8 research projects (and member the team of 12 other research projects). Funding Agencies: Fundação para a Ciência e a Tecnologia, Ministério da Educação e Ciência, Fundação Calouste Gulbenkian, Ministério da Saúde, Conselho de Reitores das Universidades Portuguesas (Portugal), European Union.
Refereeing activities : Member of the evaluation panel of Individual Doctoral and Post-doctoral Grant proposals - area Biomedical Sciences and Basic Medicine -2013 and 2014 -Fundação para a Ciência e a Tecnologia – Ministério da Educação e Ciência de Portugal. Expert Evaluator for the “MRC South Africa 2013- 214” calls (area Tuberculosis). Member of the Review and Advisory Panel of the ‘Wellcome Trust Awards 2014”. Member of the evaluation panels for the QREN R&D investment proposals of the Ministério da Economia de Portugal. Consultant of the Ministério da Saúde de Portugal (Área Tuberculosis). Regular reviewer of several international journal manuscripts. Academic and Science Management activities: 2005 – present - Elected member of the General Council of the IHMT/UNL. 2009 - present - Elected member of the Scientific Council of the IHMT/UNL. 2006 - 2014 – Member of the Directive Committee of the Portuguese Board of Biologists (Ordem dos Biólogos) 2010 - 2014 - Founding member and Treasurer of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycobacterial Infections. https://www.escmid.org/index.php?id=897