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Nicolas Svetec

  • PhD
  • Senior Research Associate with Li Zhao
  • The Rockefeller University, New York, (USA)
  • 8h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 181CitationsNumber of citations received by Nicolas's publications. Updated daily.

Other IDs

Research interests

DrosophilaInsect PhysiologyAnimal BehaviorPopulation GeneticsGenomicsGeneticsEvolutionary Biology

About

I am an evolutionary biologist with a particular interest in the genetics of adaptation. One of the key question in evolutionary biology is the understanding of the forces maintaining phenotypic and genetic variation within species. As local adaptation is one of these forces, my research activities focus on the investigation of traits under spatially varying selection. Rapid allele frequency changes under positive selection may leave footprints at the DNA level (like selective sweeps). Genomic scans for these footprints thus allow one to identify genetic variants involved in local adaptation. I then investigate the biological function of those variants by integrating physiological, behavioral, genetic and gene expression approaches. I use Drosophila melanogaster and some of its sister species as model organisms because their genetics and historical biogeography is well characterized and because they offer a very unique panel of molecular tools to study the genetics of adaptation. I started to work with Drosophila species during my masters’ degree. Under the supervision of Jean-Francois Ferveur (UB, Dijon, France), I manipulated the production and the perception of some cuticular hydrocarbons and studied the consequences on mating behavior and male-male interactions. Then, I joined the group of Wolfgang Stephan in LMU Munich (Germany) where I built a PhD project mixing QTL mapping and selective sweep mapping. It aimed at getting a better understanding of how D. melanogaster could adapt to the cold European climate. After my PhD, I moved to University of Toronto (Canada) for a postdoc under the supervision of Locke Rowe and Marla Sokolowski where I studied the effects of different alleles of the foraging gene on the behavior and the life history of D. melanogaster. I joined the Begun lab at UC Davis in California in 2011 to study spatially varying selection (i.e. latitudinal clines) in Drosophila species. My current research work integrates recombineering, genetic engineering, transgenics, transcriptomics, and genomics to study latitudinal clines in Drosophila - in particular for phenotypes linked to DNA repair and circadian rhythms (sleep).

Co-authors (28)

  • Brent L. Lockwood

Publications (11)

Seasonal cues induce phenotypic plasticity of Drosophila suzukii to enhance winter survival

  • Shearer P
  • West J
  • Walton V
BMC Ecology (2016)
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The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster

  • Svetec N
  • Cridland J
  • Zhao L
PLOS Genetics (2016)
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Evidence that natural selection maintains genetic variation for sleep in Drosophila melanogaster

  • Svetec N
  • Zhao L
  • Saelao P
BMC Evolutionary Biology (2015)
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Parallel Gene Expression Differences between Low and High Latitude Populations of Drosophila melanogaster and D. simulans

  • Zhao L
  • Wit J
  • Svetec N
PLOS Genetics (2015)
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Identification of X-linked quantitative trait loci affecting cold tolerance in Drosophila melanogaster and fine mapping by selective sweep analysis

  • Svetec N
  • Werzner A
  • Wilches R
Molecular Ecology (2011)
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Professional experience

Senior Research Associate with Li Zhao

The Rockefeller University, New York, (USA)

March 2017 - Present

Post-Doctoral Fellow with David Begun

University of California - Davis, (USA)

August 2011 - February 2017(6 years)

Post Doctoral Fellow with M. Sokolowski and L. Rowe

University of Toronto, (Canada)

July 2009 - August 2011(2 years)

Research Assistant with J-F. Ferveur

University of Burgundy, Dijon, (France)

September 2003 - February 2005(a year)

Education history

PhD in Evolutionary Biology

University of Munich, (Germany) with W. Stephan

April 2005 - April 2009(4 years)

Master 2 in Ecophysiology and Behavior

Université Louis Pasteur (France)

September 2002 - September 2003(a year)

Master 1 in Populations Biology

University of Burgundy, Dijon, (France)

September 2001 - September 2002(a year)

Bachelor's Degree in Biology

Université Grenoble 1, (France)

September 2000 - September 2001(a year)

University Diploma in Biology

Université Grenoble 1, (France)

September 1998 - September 2000(2 years)