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Nikos Karamanos

  • Ph.D., ERT, Professor
  • Professor of Biochemistry
  • University of Patras
  • 46h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 9174CitationsNumber of citations received by Nikos's publications. Updated daily.


Research interests My research fields are Matrix Biology, Cell Signaling, Functional Cell Properties, Pharmacological Targeting at Molecular and Cellular Levels, Biological Testing, Cell mimetic models for cancer metastasis, Structure Analysis of glycosaminoglycans and Evaluation of Cytotoxicity. • Evaluation of pharmacological agents at molecular and cellular levels (functional cell properties, receptors and intracellular pathways, gene expression and regulation) • Health and Safety issues: toxicity evaluation at cell level • Development, validation and biological applications of high-performance liquid chromatographic & capillary electrophoresis methods for fine biochemical and structural analysis of carbohydrates, proteoglycans and glycoproteins in biological samples (Cell cultures, tissues, biological matrices) • Structure, analysis and interactions of important biological molecules (growth factors/peptides, amino acid derivatives) Guest editor/editor 1. International Book Edition: Extracellular Matrix: Pathobiology and Signaling (Nikos Karamanos Editor), ISBN 978-3-11-025876-9 (2012), Walter DeGruyter, Berlin/Boston 2. Special Issue (N. Karamanos, guest editor): Matrix-mediated cell behavior and properties, Biochimica et Biophysica Acta-General Subject (2014) 3. MiniReview Series (N. Karamanos and A. Passi, coordinators): Novel insights into matrix pathobiology regulatory mechanisms in health and disease , FEBS J, 2014 4. Special Isuue (N. Karamanos and R. Linhardt, coordinators): Proteoglycans signaling, targeting and therapeutics, FEBS J (2013) 280 (10), 2119–2534 5. MiniReview Series (V. Hascall and N. Karamanos, coordinators): Regulatory roles of hyaluronan in health and disease, FEBS J, Vol. 278(9) (2011) 6. MiniReview Series (H. Nagase and N. Karamanos, coordinators): Metalloproteinases in Health and Disease: challenges and the future prospects, FEBS J, Vol. 278(1) (2011) 7. MiniReview Series (R. Iozzo and N. Karamanos, coordinators): Proteoglycans in Health and Disease: emerging concepts and future directions, FEBS J, Vol. 277 (2010) 8. Special issue: Matrix Pathobiology, Signaling and Molecular Targets, Conn. Tissue Res. (2008) Vol. 49, issues 2 & 3. 9. Special issue: Solid phase assays for molecules with biopharmaceutical importance, J. Pharm. Biomed. Analysis, Elsevier, Vol. 34 (2004). 10. Special issue: CE of carbohydrates (Analysis of carbohydrate macromolecules by capillary electrophoresis: glycoproteins, proteogycans/glycosaminoglycans and glycolipids), Biomedical Chromatography, Wiley Interscience, Vol. 16 (2002).


Matrix Biology

Associate Editor

2015 - Present

Plos One

Academic Editor

2011 - Present

Recent publications

  • The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery

    • Afratis N
    • Klepfish M
    • Karamanos N
    • et al.
  • Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors

    • Karalis T
    • Heldin P
    • Vynios D
    • et al.

Professional experience

Professor of Biochemistry

University of Patras

July 2003 - Present

Co-authors (458)