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Paul Dalby

  • PhD
  • Professor
  • University College London
  • 24h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 1705CitationsNumber of citations received by Paul's publications. Updated daily.

Other IDs

Research interests

Enzyme engineering Protein engineering Directed Evolution Protein Formulation

About

Paul Dalby is a Professor in Biochemical Engineering and Biotechnology at University College London, where he has been a principle investigator since April 2000. His interests are in protein engineering, formulation, synthetic biology, high-throughput microscale and microfluidic techniques, and biophysical studies which aim to address key challenges in developing industrial bioprocesses. For example, he has used directed evolution and bioinformatics to improve biocatalytic enzymes under biotransformation process conditions. He has also co-developed novel de novo pathways to chiral amino-diols in E .coli. Finally he has developed several microwell and microfluidic based techniques to rapidly screen protein stability, folding and function, useful in protein engineering and biopharmaceutical formulation. He graduated with a Natural Sciences degree from the University of Cambridge and received his PhD in 1998, also from the University of Cambridge, for work on protein engineering and protein folding under the guidance of Sir Prof Alan Fersht. He then undertook a Postdoctoral research fellowship at the University of Pennsylvania in the laboratory of Prof William DeGrado in collaboration with Ron Hoess at DuPont (Wilmington, Del.), to engineer WW domain proteins using phage display techniques. Since July 2008 Paul has been Chair of the Royal Society of Chemistry’s Biotechnology Subject Group which aims to engage academia, industry and the public in debate and scientific discussion on advances in Biotechnology. He received the Evonik European Science-to-Business Award in November 2008 for his work on engineering enzyme routes for the production of chiral intermediates.

Co-authors (135)

Publications (5)

  • An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates

    • Cárdenas-Fernández M
    • Bawn M
    • Hamley-Bennett C
    • et al.
    N/AReaders
    0Citations
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  • Modelling and optimisation of the one-pot, multi-enzymatic synthesis of chiral amino-alcohols based on microscale kinetic parameter determination

    • Rios-Solis L
    • Morris P
    • Grant C
    • et al.
    N/AReaders
    13Citations
    Get full text
  • Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes

    • Grant C
    • Deszcz D
    • Wei Y
    • et al.
    N/AReaders
    24Citations
    Get full text
  • Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells

    • Patterson R
    • Nerren J
    • Kogut M
    • et al.
    N/AReaders
    6Citations
    Get full text
  • A toolbox approach for the rapid evaluation of multi-step enzymatic syntheses comprising a 'mix and match' E. coli expression system with microscale experimentation

    • Rios-Solis L
    • Halim M
    • Cazares A
    • et al.
    N/AReaders
    12Citations
    Get full text

Professional experience

Professor

University College London

September 2013 - Present

Reader

UCL - University College London

September 2009 - September 2013(4 years)

Senior Lecturer

UCL - University College London

September 2007 - September 2009(2 years)

Lecturer

UCL - University College London

April 2000 - September 2007(7 years)

Education history

PostDoc with William F DeGrado

University of Pennsylvania

January 1998 - February 2000(2 years)

PhD with Sir Prof Alan R Fersht

University of Cambridge (MRC-Centre for Protein Engineering)

September 1994 - January 1998(3 years)

MA in Natural Sciences (1st Class)

Gonville and Caius College, University of Cambridge

September 1991 - August 1994(3 years)