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Paul Fowler

  • Chair in Translational Medical Sciences
  • 98PublicationsNumber of items in Paul's My Publications folder on Mendeley.
  • 6Followers

Research interests

http://www.abdn.ac.uk/ims/staff/details.php?id=p.a.fowler

About

I graduated from the University of Aberdeen in 1982 with a First Class Honours degree in Zoology and then went on to do my PhD with Professor Paul Racey, Department of Zoology, University of Aberdeen, ending in 1986. This work was on "Aspects of Reproduction & Heterothermy in Seasonally Breeding Mammals", in particular the European hedgehog and badger. I spent the next 3 years as a post-doctoral researcher with Professor Margaret Foster (Department of BioMedical Physics, University of Aberdeen), during which time we produced some of the seminal work on the use of MRI for the analysis of body composition and mammary gland function with collaborators at the Rowett Research and Hannah Institutes. In 1989 I moved to the Department of Obstetrics & Gynaecology, University of Aberdeen, to work with Professor Allan Templeton on ovarian hormones and antiprogesterones. I have spent much of my career working on elucidating mechanisms in the regulation of reproduction and the interactions between different components of the reproductive system. At each stage I have made contributions in the use of technologies to answer reproductive questions. These have included: the use of remote telemetry to monitoring body-testis temperature differentials and other aspects of thermal biology, the application of phage libraries and protein purification techniques to the investigation of reproductive proteins and seminal contributions to the use of MRI in the study of body composition, development and mammary gland function. In the new century I moved to the Institute of Medical Sciences, University of Aberdeen as a Professor of Translational Medical Sciences. Currently, I am also employing proteomics and other techniques in the search for diagnostic and therapeutic biomarkers for endometriosis. However, over the decade my research has primarily focused on investigating the effects of endocrine disruption on fetal development in both human and animal models. Grants: Fowler PA, Templeton A, The interaction between non-steroidal factors and oestradiol in the regulation of the LH surge, SOHHD, £3,750, 1990, 0.5 yr Fowler PA, Equipment grant for a manual isocratic chromatography system, University Research Committee, £10,328, 1991, Fowler PA, Irvine DS, The effects of different molecular mass fractions of follicular fluid on aspects of sperm function, SOHHD, £3,585, 1991, 0.75 yr Fowler PA, Inter-faculty large equipment grant for a DELFIA system, Faculty of Medicine, £26,920, 1991, Fowler PA, The purification of gonadotrophin surge-attenuating factor and study of its mechanism of action and importance in the regulation of the menstrual cycle in women, Scottish Hospital Endowments Trust, £66,155, 1992, 2 yr Hamilton M, Fowler PA, The magnitude and persistence of effect of simultaneous GH and hMG administration on ovarian response to superovulation, Grampian Health Board & Serono Laboratories (UK) Ltd, £2,490, 1992, 1 yr Hamilton M, Fowler PA, Templeton A, Equipment grant for a Sonoline ultrasound scanner, University Research Committee, £23,295, 1992, Fowler PA, Equipment Grant for a high speed centrifuge, University Research Committee, £5,301, 1993, Fowler PA, Equipment Grant for half the costs of a perfusion system, University Research Committee, £12,065, 1993, Fowler PA, Templeton A, The effects of GnSAF and RU486 on GnRH-induced LH surges, University Research Committee MSc Studentship, £11,063, 1994, 1.25 yr Fowler PA, Templeton A, Control of pituitary function during the LH surge, Tenovus (equipment), £12,065, 1994, Fowler PA, Melvin WT, The molecular biology of human ovarian gonadotrophin surge-attenuating factor (GnSAF), ACTR, £24,801, 1994, 3 yr Fowler PA, Equipment Grant for a robotic liquid handling station, University Research Committee, £22,000, 1994, Fowler PA, Isolation of human GnSAF (equipment), Royal Society, £2,152, 1995, Fowler PA, Melvin WT, Production of recombinant GnSAF and in vitro effects of highly purified GnSAF, MRC, £28,756, 1995, 1 yr Fowler PA, Circulating inhibins during human pregnancy, Serono Laboratories (UK) Ltd, £1,000, 1996, 1 yr Fowler PA, Wallace H, Abramovich DR, Effect of the oestrogenic toxicants dieldrin and toxaphene on testosterone and inhibin B secretion from human fetal testicular explants, Aberdeen Royal Hospitals Endowment Trust, £4,980, 1997, 1 yr Sahota S, Fowler PA & Haites N, Identification of differentially expressed genes in polycystic ovarian syndrome, University Research Committee, £7,450, 1997, 1 yr Fowler PA, Lea RG, Haites N, Abramovich DR, Do environmental toxicants affect fetal gonadal development and induce changes which may predispose to cancer in the adult?, Dr James Alexander Mearn’s Trust, £42,557, 1997, 3 yr Martinez F, Knight PG, Groome, NP, Barri PN, Coroleu V, Tur R, Fowler PA, GnSAF/IF in low response & sponataneous ovulation in stimulated cycles under GnRH suppression during IVF, Ares-Serono, £9,530, 1998, 1 yr Fowler PA, Haites, N, Shaw, D, Booth N, Funding under the Aberdeen Fetal Research Initiative, Research Theme Funding, University of Aberdeen, £21,200, 1998, Fowler P.A, Abramovich DR, Funding under the Molecular Pathology Theme, Research Theme Funding, University of Aberdeen, £10,550, 1998, Fowler PA, Harris W, Isolation of ovarian GnSAF/IF from granulosa cell-conditioned medium, BBSRC, £100,828, 1999, 2 yr Bell C, Sahota S, Fowler PA, Templeton A, Haites N, Investigation and analysis of polymorphoc regions in candidate genes involved in polycystic ovarian syndrome (PCOS), Chief Scientist Office, £85,494, 1999, 2 yr Fowler PA, Abramovich DR, Funding under the Molecular Pathology Theme, Research Theme Funding, University of Aberdeen, £4,713, 1999, Gazvani MR, Fowler PA, Haggarty P, Odds FC, Gow, N, Templeton A, Does Candida albicans play a role in the etiology of endometriosis?, Endometriosis Association, £21,500, 2000, 1 yr Fowler PA, Sweeney T, The effects of maternal exposure to the EDC octylphenol on protein synthesis in the sheep mammary gland, Enterprise Ireland/British Council, £2,800, 2001, Huhtaniemi I, Fowler PA, Cash P, Charlton H, Novel biological actions of luteinizing hormone and its receptor, Wellcome Trust, £1,408,031, 2001, 5 yr Fowler PA, Harris W, Mason HD, Characterisation of ovarian GnSAF/IF, BBSRC, £72,472, 2001, 1 yr Fowler PA, Bhattacharya S, Cash P, Establishing a relationship between endometrial proteins and endometriosis, GUHT Endowments, £5,250, 2003, 1 yr Cruickshank M, Fowler PA, Cruden Medical Research Scholarship: Lichen sclerosus, SHERT, £34,707, 2003, 1 yr Shanbhag S, Bhattacharya S, Fowler PA, Sahota S, Role of gonadotrophin and gonadotrophin receptor polymorphisms in ovarian function, Tenovus, £5,615, 2003, 1 yr Lea RG, Fowler PA, Al-Gubory K, Sandra O, The role of progesterone in immuno-endocrine signalling during normal and nutritionally growth restricted sheep pregnancies, British Council/Alliance Travel, £4,100, 2004, 2 yr Martinez F, Coroleu B, Fowler PA, Bhattacharya S, Effect of steroidal pre-treatment on ovarian parameters during IVF, Organon, £16,848, 2004, 1 yr Fowler PA, Bhattacharya S, Optimisation of an in-vitro model to investigate the human fetal testis, CSO, £15,571, 2004, 1 yr Fowler PA, Bhattacharya S, Cash P, Establishing a relationship between endometrial proteins and endometriosis, CSO, £18,856, 2004, 1 yr Shanbhag S, Cruickshank M, Millier I, Murray G, Fowler PA, Molecular basis of granulosa cell tumours, NHS Grampian Endowments, £11,343, 2004, 1.5 yr Fowler PA, Bhattacharya S, Cash P, Circulating biomarkers for endometriosis, University of Aberdeen Commercialisation Fund, £19,095, 2006, 1 yr Fowler PA, Bhattacharya S, Hamilton MPR, al-Gubory K, Identification of implantation-related proteins, NHS R&D, £18,500, 2006, 1 yr Skaare JU et al, Fowler PA, The mechanisms behind toxic effects of POPS, NFR, £170,377, 2006, 3 yr Fowler PA, Wood M, Human fetal gonad: 2 summer research studentships, SRF, £2,640, 2006, 8 wks Fowler PA, Maheshwari A, Bhattacharya S, Follicular assembly in the human fetal ovary, IMS Microarray Core Facility grant, UoA, £6,000, 2006, 12 wks Fowler PA, Sharpe R, Cotinot C, Rhind S, Evans N, Effect of in-utero exposure to environmental chemicals via maternal pasture ingestion on fetal development, Wellcome Trust, £425,786, 2007, 3 yr Fowler PA, Sharpe R, Cotinot C, Rhind S, Evans N, Salary supplement for Wellcome project “Effect of in-utero exposure to environmental chemicals via maternal pasture ingestion on fetal development.”, NHS R&D, £10,000, 2007, 1 yr Bhattacharya S, Collie-Duguid E, Fowler PA, Characterisation of dysfunctional endometrium of uterine fibroids, TMRI Ltd, £245,580, 2007, 2 yr Fowler PA, Rhind SM, Bhattacharya S, Lea RG, Sinclair K, Cotinot C, Fischer B, Pocar P, Reproductive effects of environmental chemicals in females, FW7 (€2,924,083), £2,646,605, 2008, 3.5 yr Fowler PA, Millar RM, Duncan C, Horne A, Logan J, Pickett J, Birkett M, Bhattacharya S, Jack S, Identification of endometriosis biomarkers in urine, TMRI Ltd, £549,765, 2008, 2 yr Fowler PA, Rhind SM, Bhattacharya, S, O’Shaughnessy PJ, Does maternal smoking disrupt key developmental sex steroid hormones in the fetus?, NHS Grampian Endowments, £10,834, 2008, 1 yr Fowler PA, Cotinot C, O’Shaughnessy PJ, Inter-species comparison of the onset ovarian follicle formation, Wellcome Trust summer studentship, £5,760, 2008, 0.15 yr Fowler PA, Harkany T, O’Shaughnessy PJ, Fetal human gonadal cannabinoid receptors: expression and effects of maternal smoking, NHS Grampian Endowments, £6,713, 2009, 1 yr Fowler PA, O’Shaughnessy PJ, Effect of maternal cigarette smoking on markers of primordial follicle formation in the human fetus, SRF summer studentship, £1,440, 2009, 0.15 yr Fowler PA, Rhind SM, Effect of in-utero EDC exposure on the fetal ovary during specific windows of development, Development Trust summer studentship, £1,200, 2009, 0.15 yr Fowler PA, Collinson JM, O’Shaughnessy PJ, Bioincubator system to model toxic effects on the human fetal testis, CSO, £62,078, 2009, 1 yr Fowler PA, Small equipment grant, University of Aberdeen, £1,485, 2009, Fowler PA, McKinlay R, The effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls via maternal ingestion on the foetal sheep ovary, Holly Hill Trust, £10,000, 2010, 0.25 yr Fowler PA, O’Shaughnessy PJ, Does maternal cigarette cell specific developmental markers in the human fetal testis?, SRF summer studentship, £1,440, 2010, 0.15 yr Fowler PA, O’Shaughnessy PJ, McCaffery P, The retinoic acid pathway in the human fetal gonad and the effects of maternal smoking, Development Trust summer studentship, £1,200, 2010, 0.15 yr Fowler PA, Bhattacharya A, Validation of two candidate biomarker molecules for the diagnosis of endometriosis, KETF, £12,000, 2011, 0.15 yr Total £ raised since 1990, 6,255,391, (€6,883,145)

Followers (6)

Following (1)

Recent publications

  • Estrogen-independent actions of environmentally relevant AhR-agonists in human endometrial epithelial cells.

    • Willing C
    • Peich M
    • Danescu A
    • et al.
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  • Maternal and fetal tissue accumulation of selected endocrine disrupting compounds (EDCs) following exposure to sewage sludge-treated pastures before or after conception.

    • Rhind S
    • Kyle C
    • Mackie C
    • et al.
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