Paul Jaschke

Post-doctoral Researcher

Department of Bioengineering, Stanford University

Location
Stanford, California, United States
Discipline
Biological Sciences
Interests
Bacteriophage, Genome design and assembly, Bioengineering, synthetic biology
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About

I am currently a post-doc in Drew Endy's lab at Stanford University. The focus of my project is to redesign phage using both rational and combinatorial methods in order to finish the genetics of a simple system.

I started off my science career at the University of Alberta (Canada), working in the Casey and Michalak labs. Summer student work in the Casey Lab on the human sodium-bicarbonate co-transporter protein resulted in an authorship in a peer-reviewed publication. My honors project in the Michalak Lab had me determining the role of calcium signalling and calreticulin on murine embryonic stem cell differentiation. After achieving a B.Sc. (Honors) in Biochemistry in 2003 I went to the Beatty Lab at the University of British Columbia to start my Ph.D. While at UBC I discovered that a photosynthetic organism called Rhodobacter sphaeroides was capable of re-routing its chlorophyll biosynthetic machinery around a blockage to generate a new type of chlorophyll. November 2010 I was conferred a Ph.D in Microbiology and Immunology from UBC.
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Publications

A fully decompressed synthetic bacteriophage øX174 genome assembled and archived in yeast.

Jaschke P, Lieberman E, Rodriguez J, Sierra A, Endy D

Virology (2012)

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Electron transfer in Rhodobacter sphaeroides reaction centers containing Zn-bacteriochlorophylls: a hole-burning study.

Neupane B, Jaschke P, Saer R, Beatty J, Reppert M, Jankowiak R

The journal of physical chemistry. B (2012)

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A bchD (magnesium chelatase) mutant of Rhodobacter sphaeroides synthesizes zinc bacteriochlorophyll through novel zinc-containing intermediates.

Jaschke P, Hardjasa A, Digby E, Hunter C, Beatty J

The Journal of Biological Chemistry (2011)

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The photosystem of Rhodobacter sphaeroides assembles with zinc bacteriochlorophyll in a bchD (magnesium chelatase) mutant.

Jaschke P, Beatty J

Biochemistry (2007)

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The PucC protein of Rhodobacter capsulatus mitigates an inhibitory effect of light-harvesting 2 alpha and beta proteins on light-harvesting complex 1.

Jaschke P, Leblanc H, Lang A, Beatty J

Photosynthesis research (2008)

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Electron transfer in the Rhodobacter sphaeroides reaction center assembled with zinc bacteriochlorophyll.

Lin S, Jaschke P, Wang H, Paddock M, Tufts A, Allen J et al.

Proceedings of the National Academy of Sciences of the United States of America (2009)

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Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain.

Loiselle F, Jaschke P, Casey J

Molecular Membrane Biology (2003)

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Modification of a French pressure cell to improve microbial cell disruption.

Jaschke P, Drake I, Beatty J

Photosynthesis research (2009)

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Analysis of reaction center assembly in Rhodobacter sphaeroides

Jaschke P

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Professional experience

Post-doctoral Researcher

Department of Bioengineering, Stanford University

November 2010 - Present

Research Technician

Department of Chemistry, University of Queensland

May 2004 - July 2004 (2 months)

Education history

University of British Columbia, Department of Microbiology and Immunology

Ph.D.

September 2004 - August 2010 (5 years 11 months)

University of Alberta, Department of Biochemistry

B.Sc.

September 1999 - June 2003 (3 years 9 months)