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Paul Ornstein

  • Dr
  • Associate Professor of Medicinal Chemistry
  • Medical College of Wisconsin
  • 45h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 5820CitationsNumber of citations received by Paul's publications. Updated daily.


I am an accomplished medicinal chemist in the neuroscience area, having delivered 8 clinical candidates for neurological and psychiatric disorders. My work at Lilly has resulted in 53 issued US patents. I have published 115 papers and given 53 invited lectures on my scientific work. I have also had an active involvement in the international scientific community, as the Chair of the 1998 Heterocyclic Compounds GRC, and as the organizer of many scientific sessions at US and European meetings as well as role on the Long Range Planning Committee of the ACS Division of Medicinal Chemistry. I am also a member of the NIH Study Section NSD-B for Translational Research in Neurodegenerative Disorders.

Recent publications

  • Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

    • Chappell M
    • Li R
    • Smith S
    • et al.
  • Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8

    • Gardinier K
    • Gernert D
    • Porter W
    • et al.

Professional experience

Associate Professor of Medicinal Chemistry

Medical College of Wisconsin

July 2017 - Present

Associate Professor of Medicinal Chemistry

Roosevelt University

July 2012 - June 2017(5 years)

Senior Research Fellow

Eli Lilly & Company

October 2005 - June 2012(7 years)

Research Fellow

Eli Lilly & Company

January 1998 - October 2005(8 years)

Senior Research Scientist

Eli Lilly & Company

January 1993 - December 1997(5 years)

Research Scientist

Eli Lilly & Company

January 1989 - December 1992(4 years)

Senior Organic Chemist

Eli Lilly & Company

August 1984 - December 1988(4 years)



Harvard University, Department of Chemistry and Chemical Biology

August 1983 - June 1984(10 months)


California Institute of Technology

May 1982 - August 1983(a year)


Department of Chemistry, University of Wisconsin at Madison

June 1977 - May 1982(5 years)


University of California Los Angeles Department of Chemistry and Biochemistry

September 1973 - June 1977(4 years)

Co-authors (370)

  • Maria-Jesus Blanco