Mendeley Advisor Philip Fowler

  • PhD
  • Postdoctoral Researcher
  • SBCB Unit, Department of Biochemistry, University of Oxford

Research Interests

Computational Biophysics Membrane Proteins Free energy calculations Mechanics and physics of proteins

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Publications

Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter.

Samsudin F, Parker J, Sansom M, Newstead S, Fowler P

Cell Chem Biol (2016)

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Alchembed: A computational method for incorporating multiple proteins into complex lipid geometries.

Jefferys E, Sands Z, Shi J, Sansom M, Fowler P

J Chem Theo Comp (2015)

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Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport

Beale J, Parker J, Samsudin M, Barrett A, Senan A, Bird L, Scott D, Owens R, Sansom M, Tucker S, Meredith D, Fowler P, Newstead S

Structure (2015)

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Gating topology of the proton coupled oligopeptide symporters.

Fowler P, Orwick-Rydmark M, Solcan N, Dijkman P, Lyons, Joseph A, Kwok J, Caffrey M, Watts A, Forrest L, Newstead S

Structure (2015)

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Nothing to Sneeze At: A Dynamic and Integrative Computational Model of an Influenza A Virion

Reddy T, Shorthouse D, Parton D, Jefferys E, Fowler P, Chavent M, Baaden M, Sansom M

Structure (2015)

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Flexible Gates Generate Occluded Intermediates in the Transport Cycle of LacY

Stelzl L, Fowler P, Sansom M, Beckstein O

J Mol Biol (2014)

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Insights into the structural nature of the transition state in the Kir channel gating pathway

Fowler P, Bollepalli M, Rapedius M, Nematian E, Shang L, Sansom M, Tucker S, Baukrowitz T

Channels (2014)

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NRas slows the rate at which a model lipid bilayer phase separates

Jefferys E, Sansom M, Fowler P

Faraday Discuss (2014)

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State-dependent network connectivity determines gating in a K+ channel.

Bollepalli M, Fowler P, Rapedius M, Shang L, Sansom M, Tucker S, Baukrowitz T

Structure (2014)

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Detailed Examination of a Single Conduction Event in a Potassium Channel

Fowler P, Beckstein O, Abad E, Sansom M

J Phys Chem Lett (2013)

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Energetics of multi-ion conduction pathways in potassium ion channels

Fowler P, Abad E, Beckstein O, Sansom M

J Chem Theory Comput (2013)

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The pore of voltage-gated potassium ion channels is strained when closed.

Fowler P, Sansom M

Nature Comms (2013)

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Alternating access mechanism in the POT family of oligopeptide transporters.

Solcan N, Kwok J, Fowler P, Cameron A, Drew D, Iwata S, Newstead S

EMBO J (2012)

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Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2.

Newstead S, Drew D, Cameron A, Postis V, Xia X, Fowler P, Ingram J, Carpenter E, Sansom M, McPherson M, Baldwin S, Iwata S

EMBO J (2011)

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Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.

Paynter J, Andres-Enguix I, Fowler P, Tottey S, Cheng W, Enkvetchakul D, Bavro V, Kusakabe Y, Sansom M, Robinson N, Nichols C, Tucker S

J Biol Chem (2010)

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A Novel Rate Theory Approach To Transport In Ion Channels

Abad E, Reingruber J, Fowler P, Sansom M, Wei D, Wang X

AIP Conf Proc (2009)

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Insights into how nucleotide-binding domains power ABC transport.

Newstead S, Fowler P, Bilton P, Carpenter E, Sadler P, Campopiano D, Sansom M, Iwata S

Structure (2009)

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Helix-helix interactions in membrane proteins: coarse-grained simulations of glycophorin a helix dimerization.

Psachoulia E, Fowler P, Bond P, Sansom M

Biochemistry (2008)

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Molecular modeling and simulation studies of ion channel structures, dynamics and mechanisms.

Tai K, Fowler P, Mokrab Y, Stansfeld P, Sansom M

Methods in Cell Nano Biology (2008)

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The selectivity of K+ ion channels: testing the hypotheses.

Fowler P, Tai K, Sansom M

Biophys J (2008)

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Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.

Rapedius M, Paynter J, Fowler P, Shang L, Sansom M, Tucker S, Baukrowitz T

Channels (2007)

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H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

Rapedius M, Fowler P, Shang L, Sansom M, Tucker S, Baukrowitz T

Neuron (2007)

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Monotopic enzymes and lipid bilayers: a comparative study.

Fowler P, Balali-Mood K, Deol S, Coveney P, Sansom M

Biochemistry (2007)

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Rapid, accurate, and precise calculation of relative binding affinities for the SH2 domain using a computational grid

Fowler P, Geroult S, Jha S, Waksman G, Coveney P

J Chem Theory Comput (2007)

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A computational protocol for the integration of the monotopic protein prostaglandin H2 synthase into a phospholipid bilayer.

Fowler P, Coveney P

Biophys J (2006)

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Qualitative and Quantitative Aspects of Biomolecular Systems Revealed by Large Scale and Grid Computing Methods

Fowler P

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Grid-based steered thermodynamic integration accelerates the calculation of binding free energies.

Fowler P, Jha S, Coveney P

Phil Trans R Soc Lond A (2005)

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Large scale molecular dynamics simulation of native and mutant dihydropteroate synthase-sulphanilamide complexes suggests the molecular basis for dihydropteroate synthase drug resistance.

Giordanetto F, Fowler P, Saqi M, Coveney P

Phil Trans R Soc Lond A (2005)

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Modelling biological complexity: a physical scientist's perspective.

Coveney P, Fowler P

J R Soc Lond Interface (2005)

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Exact calculation of peptide-protein binding energies by steered thermodynamic integration using high performance computing grids

Fowler P, Coveney P, Jha S, Wan S

Proceedings of the UK e-Science All Hands Meeting (2004)

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Lattice-Gas Simulations of Ternary Amphiphilic Fluid Flow in Porous Media

Coveney P, Maillet J, Wilson J, Fowler P, Al-Mushadani O, Boghosian B

Int J Mod Phys C (1998)

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Professional experience

Postdoctoral Researcher

SBCB Unit, Department of Biochemistry, University of Oxford

February 2006 - Present

Junior Research Fellow

St John's College, Oxford

October 2008 - September 2012 (3 years 11 months)

Education history

University College London Department of Chemistry

PhD

August 2002 - February 2006 (3 years 6 months)

University of Cambridge Clare College

MSci in Natural Sciences (Physics)

October 1994 - June 1998 (3 years 8 months)