Philip Fowler PhD

Postdoctoral Researcher

SBCB Unit, Department of Biochemistry, University of Oxford

City
Oxford, United Kingdom
Discipline
Biological Sciences
Interests
Computational Biophysics Membrane Proteins Free energy calculations Mechanics and physics of proteins
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Publications

  • Gating topology of the proton coupled oligopeptide symporters.

    Fowler P, Orwick-Rydmark M, Solcan N, Dijkman P, Lyons, Joseph A, Kwok J et al.

    Structure (2015)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Nothing to Sneeze At: A Dynamic and Integrative Computational Model of an Influenza A Virion

    Reddy T, Shorthouse D, Parton D, Jefferys E, Fowler P, Chavent M et al.

    Structure (2015)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Insights into the structural nature of the transition state in the Kir channel gating pathway

    Fowler P, Bollepalli M, Rapedius M, Nematian E, Shang L, Sansom M et al.

    Channels (2014)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • NRas slows the rate at which a model lipid bilayer phase separates

    Jefferys E, Sansom M, Fowler P

    Faraday Discussions (2014)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Flexible Gates Generate Occluded Intermediates in the Transport Cycle of LacY

    Stelzl L, Fowler P, Sansom M, Beckstein O

    J Mol Biol (2014)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Detailed Examination of a Single Conduction Event in a Potassium Channel

    Fowler P, Beckstein O, Abad E, Sansom M

    J Phys Chem Lett (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Energetics of multi-ion conduction pathways in potassium ion channels

    Fowler P, Abad E, Beckstein O, Sansom M

    J Chem Theory Comput (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • State-dependent network connectivity determines gating in a K+ channel.

    Bollepalli M, Fowler P, Rapedius M, Shang L, Sansom M, Tucker S et al.

    Structure (2014)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Lattice-Gas Simulations of Ternary Amphiphilic Fluid Flow in Porous Media

    Coveney P, Maillet J, Wilson J, Fowler P, Al-Mushadani O, Boghosian B

    Int J Mod Phys C (1998)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The pore of voltage-gated potassium ion channels is strained when closed.

    Fowler P, Sansom M

    Nature Comms (2013)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Alternating access mechanism in the POT family of oligopeptide transporters.

    Solcan N, Kwok J, Fowler P, Cameron A, Drew D, Iwata S et al.

    EMBO J (2012)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Exact calculation of peptide-protein binding energies by steered thermodynamic integration using high performance computing grids

    Fowler P, Coveney P, Jha S, Wan S

    Proceedings of the UK e-Science All Hands Meeting (2004)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Insights into how nucleotide-binding domains power ABC transport.

    Newstead S, Fowler P, Bilton P, Carpenter E, Sadler P, Campopiano D et al.

    Structure (2009)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Molecular modeling and simulation studies of ion channel structures, dynamics and mechanisms.

    Tai K, Fowler P, Mokrab Y, Stansfeld P, Sansom M

    Methods in Cell Nano Biology (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • The selectivity of K+ ion channels: testing the hypotheses.

    Fowler P, Tai K, Sansom M

    Biophys J (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Helix-helix interactions in membrane proteins: coarse-grained simulations of glycophorin a helix dimerization.

    Psachoulia E, Fowler P, Bond P, Sansom M

    Biochemistry (2008)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A Novel Rate Theory Approach To Transport In Ion Channels

    Abad E, Reingruber J, Fowler P, Sansom M, Wei D, Wang X

    AIP Conf Proc (2009)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Rapid, accurate, and precise calculation of relative binding affinities for the SH2 domain using a computational grid

    Fowler P, Geroult S, Jha S, Waksman G, Coveney P

    J Chem Theory Comput (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Monotopic enzymes and lipid bilayers: a comparative study.

    Fowler P, Balali-Mood K, Deol S, Coveney P, Sansom M

    Biochemistry (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Qualitative and Quantitative Aspects of Biomolecular Systems Revealed by Large Scale and Grid Computing Methods

    Fowler P

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • A computational protocol for the integration of the monotopic protein prostaglandin H2 synthase into a phospholipid bilayer.

    Fowler P, Coveney P

    Biophys J (2006)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Large scale molecular dynamics simulation of native and mutant dihydropteroate synthase-sulphanilamide complexes suggests the molecular basis for dihydropteroate synthase drug resistance.

    Giordanetto F, Fowler P, Saqi M, Coveney P

    Phil Trans R Soc Lond A (2005)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Grid-based steered thermodynamic integration accelerates the calculation of binding free energies.

    Fowler P, Jha S, Coveney P

    Phil Trans R Soc Lond A (2005)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Modelling biological complexity: a physical scientist's perspective.

    Coveney P, Fowler P

    J R Soc Lond Interface (2005)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.

    Paynter J, Andres-Enguix I, Fowler P, Tottey S, Cheng W, Enkvetchakul D et al.

    J Biol Chem (2010)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2.

    Newstead S, Drew D, Cameron A, Postis V, Xia X, Fowler P et al.

    EMBO J (2011)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • H bonding at the helix-bundle crossing controls gating in Kir potassium channels.

    Rapedius M, Fowler P, Shang L, Sansom M, Tucker S, Baukrowitz T

    Neuron (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.
  • Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing.

    Rapedius M, Paynter J, Fowler P, Shang L, Sansom M, Tucker S et al.

    Channels (2007)

    • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Professional experience

Postdoctoral Researcher

SBCB Unit, Department of Biochemistry, University of Oxford

February 2006 - Present

Junior Research Fellow

St John's College, Oxford

October 2008 - September 2012 (3 years 11 months)

Education history

Department of Chemistry, University College London

PhD

August 2002 - February 2006 (3 years 6 months)

Clare College, Cambridge

MSci in Natural Sciences (Physics)

October 1994 - June 1998 (3 years 8 months)