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Pierre-François Roux

  • PhD
  • Postdoctoral Researcher
  • Johnson and Johnson Consumer France SAS
  • 8h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 208CitationsNumber of citations received by Pierre-François's publications. Updated daily.

Recent publications

  • Multi-tissue transcriptomic study reveals the main role of liver in the chicken adaptive response to a switch in dietary energy source through the transcriptional regulation of lipogenesis

    • Desert C
    • Baéza E
    • Aite M
    • et al.
    N/AReaders
    3Citations
    Get full text
  • Necroptosis microenvironment directs lineage commitment in liver cancer

    • Seehawer M
    • Heinzmann F
    • D’Artista L
    • et al.
    N/AReaders
    N/ACitations
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Professional experience

Postdoctoral Researcher

Johnson and Johnson Consumer France SAS

August 2019 - Present

Postdoctoral Researcher

Institut Pasteur

March 2015 - July 2019(4 years)

PhD candidate

INRA Site d'Agrocampus Ouest

September 2011 - December 2014(3 years)

About

Cell fate decisions entail organized changes in gene expression. A fundamental question in biology is how genes and regulatory regions are organized and coordinated for transcription regulation in these processes. Recent findings, including those of the Bischof team, have demonstrated that alterations in chromatin architecture play a decisive role in gene-regulation, but their importance in cell-fate decisions is still unclear. To close this important gap in our knowledge, we seek to explore the role of chromatin structure changes in cellular senescence, a cell-fate crucial for tumor suppression and aging. We hypothesize that active co-regulated genes and their regulatory factors coalesce in enhancer-promoter hot spots optimized for efficient and coordinated transcriptional control to enforce the senescence phenotype. To prove this hypothesis correct, we will combine genome-wide gene expression, epigenome and chromatin structure studies in cells undergoing senescence and leverage the expertise of the Bischof lab in these domains and my own expertise in high-throughput sequencing and transcriptomic data analyses.

Co-authors (221)

  • Oliver Bischof
  • Ali El-Far
  • saman aminzadeh
  • Guillou Hervé