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Ramakrishna Devaki

  • Ph.D
  • Associate Professor
  • Kamineni Institute of Medical Sciences
  • 12PublicationsNumber of items in Ramakrishna's My Publications folder on Mendeley.
  • 8Followers

Recent publications

  • Applications of G-protein coupled receptors in clinical medicine

    • P.Rao D

    • Devaki Ramakrishna
    • Sunethri Padma
    • Jijiya Bai P

Professional experience

Associate Professor

Kamineni Institute of Medical Sciences

December 2010 - Present

Assistant Professor

Kamineni Institute of Medical Sciences,

May 2007 - November 2010(4 years)



National Institute of Mental Health and Neurosciences

December 2006 - Present


I am currently a Associate Professor at the Kamineni Institute of Medical Sciences,Sreepuram, Narketpally, Nalgonda in India. I graduated in Biochemistry at the University of Manipal (India). I have a PhD in Neurochemistry at the National Institute of Mental Health and Neuroscinces, a Deemed University Institute, where I awarded Ph.D, Dec 2006. I am the member of International Brain Research Organization and I am the reviewer of science alert journals. I am also a life member of Association of Clinical Biochemistry of India. I have worked as research scholar at a National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, a premier institute in neurological health care and neuroscience research, for about four years. Here, my thesis work mainly focused on adrenergic signal transduction cascade in different regions of rat brain especially cortex and cerebellum of rat and autopsy human brain samples of various neuro psychiatric disorders, by using radioligand binding assay. This assay measures the interaction of radioligand with the receptor. In this assay, the increasing concentration of radioligand is allowed to interact with tissue preparation containing receptors in the presence and absence of cold displacer to determine the non-specific binding of radioligand. This technique is used to estimate the density and affinity of receptor. After separating the bound and free radioligand, the radioactivity present in the bound form is measured in a liquid scintillation counter. Another major part of my thesis work was Autoradiography, by using this technique I was able to trace the adrenergic receptors and its localization, on rat and human autopsy brain sections, further signal cascade alterations upon antidepressants treatment. I have estimated IP3 (Inositol tri phosphate) by using ion exchange chromatography. This study reports differential and region-specific alteration of 1-adreno ceptors, their subtypes, linked G-proteins and IP3 after chronic antidpressant and antimanic drug treatment. This adaptive mechanism of desensitization of receptors, followed by compensatory changes in the linked G-proteins and IP3 may be considered an important factor in the achievement of therapeutic efficacy of antidepressants after chronic treatment. Part of my thesis work is already published in peer reviewed International and National journals. Apart from this I also studied the effect of various antidepressants, antipsychotics, agonists, antagonists towards these receptors by displacement study, affinity of these compounds expressed in Kd values. I had the privilege of observing and performing several routine lab works in various departments like Neurophysiology, Neuropathology, Neuromicrobiology, Human genetics, Psycopharmacolgy, Biostats at NIMHANS. I published several peer-review articles related to my research interests. I am also scientific journal reviewer of various international peer reviewed journal.s I also presented my work in a number of national and international conferences, workshops and seminars. I am qualified NABL Assessor

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