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Rogier Reijmers

  • PhD.
  • Senior Postdoc Immunology/Hematology
  • VU University Medical Center
  • 12h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 422CitationsNumber of citations received by Rogier's publications. Updated daily.

Research interests

growth control and cancer. My work at the VUmc focusses on proteoglycans on stromal cells of the lymph node. The stromal cells support immune function by reciprocal interactionsSulfated proteoglycans are important macro-molecules involved in development

About

Lymph node development requires the interaction of hematopoietic- and stromal cells. A characteristic of secondary lymphoid organs is the organization of B-cells in follicles and T-cells in T-cell areas. This typical organization allows efficient B-T cell interactions and is a prerequisite to elicit a highly specific immune response. In these specific areas stromal cells support the localization and homeostasis of B- and T-cells by the secretion of cytokines like CXCL13, CCL21, and IL7. Each stromal cell subset expresses different types of oligosaccharides. These glycosaminoglycan proteoglycans can specifically immobilize and present cytokines, which postulates them as key components in determining the localization and modulation of chemokines and growth factors, thereby critically regulating lymphocyte homing, positioning, and function. In addition, a stromal-derived network can be observed that is rich of oligosaccharides, and specifically allows efficient transport of antigens into the lymph node. My research focuses on the role of these oligosaccharides in health and disease, including rheumatoid arthritis and lymphoid cancers.

Co-authors (139)

  • Serge van de Pavert

Publications (5)

  • Dendritic cell migration to skin-draining lymph nodes is controlled by dermatan sulfate and determines adaptive immunity magnitude

    • Nadafi R
    • Koning J
    • Veninga H
    • et al.
    N/AReaders
    0Citations
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  • Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8

    • Berenguer J
    • Lagerweij T
    • Zhao X
    • et al.
    N/AReaders
    0Citations
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  • IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes

    • Yang J
    • Cornelissen F
    • Papazian N
    • et al.
    N/AReaders
    0Citations
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  • Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation

    • Bar-Ephraim Y
    • Cornelissen F
    • Papazian N
    • et al.
    N/AReaders
    0Citations
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  • Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis

    • Digre A
    • Singh K
    • Åbrink M
    • et al.
    N/AReaders
    3Citations
    Get full text

Professional experience

Senior Postdoc Immunology/Hematology

VU University Medical Center

January 2013 - Present

Postdoc Immunology/Hematology

University Medical Center Rotterdam Erasmus MC

January 2010 - December 2012(3 years)

PhD Student Immunology/Hematology

Academic Medical Center

February 2003 - December 2009(7 years)

Education

MSc.

VU University of Amsterdam

September 1998 - February 2003(4 years)