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Sandra Ceccatelli

  • MD PhD
  • Professor
  • Karolinska Institutet Department of Neuroscience
  • 54h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 9624CitationsNumber of citations received by Sandra's publications. Updated daily.

About

Epidemiological and experimental data link alterations in the programming during critical periods of nervous system development to adverse consequences that increase the propensity for pathological conditions in adults. Neurotoxicology studies have shown that chemical contaminants are among the factors that have detrimental effects on neurodevelopment. Our research focuses on the mechanisms of neurodevelopmental damage that trigger alterations in cell differentiation and behavioral impairment later in life. Currently our studies focus on the developmental alterations caused by excess glucocorticoids (GC) or by oxidative stress-inducers, including chemical contaminants at levels relevant for human exposure. By using in vivo (rodents and zebrafish) as well as in vitro (rodent and human neural progenitor cells) models, and methods ranging from behavioral to single-cell analysis, we aim to: • Clarify the mechanisms behind the long-term alterations in affective behavior, i.e. depression, induced by developmental exposure to high levels of GC; • Investigate specific circadian rhythms alterations that precede the onset of depression; • Identify the molecular cascade that lead to alterations in neural progenitor cell survival and differentiation potential; • Identify potential preventive and therapeutic strategies.

Recent publications

  • Depressive-like phenotype induced by prenatal dexamethasone in mice is reversed by desipramine

    • Conti M
    • Spulber S
    • Raciti M
    • et al.
    N/AReaders
    8Citations
  • Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine

    • Spulber S
    • Conti M
    • DuPont C
    • et al.
    N/AReaders
    10Citations

Professional experience

Professor

Department of Neuroscience, Karolinska Institutet

January 2007 - Present

Head of department

Department of Neuroscience, Karolinska Institutet

January 2012 - December 2017(6 years)

Professor

Institute of Environmental Medicine, Karolinska Institutet

June 2002 - December 2006(5 years)

Associate Professor

Institute of Environmental Medicine, Karolinska Institutet

January 1999 - May 2002(3 years)

Swedish Research Council Associate professor position

Institute of Environmental Medicine, Karolinska Institutet

January 1995 - December 1998(4 years)

Swedish Research Council Associated professor position

Department of Neuroscience, Karolinska Institutet

January 1993 - December 1994(2 years)

Education

Dr Med Sci in Neurobiology

Karolinska Institutet

January 1987 - December 1991(5 years)

Child Neuropsychiatry Specialist

Universita degli Studi di Milano

September 1982 - June 1986(4 years)

MD

Universita degli Studi di Milano

September 1976 - March 1982(6 years)

Co-authors (431)

  • Osiris Ointa
  • Mirko Conti

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