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Sandy Macdonald

  • Dr
  • Postdoctoral researcher
  • University of York Department of Biology
  • 12h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 1199CitationsNumber of citations received by Sandy's publications. Updated daily.

About

After studying bacteriology during my undergraduate degree, my Ph.D. combined in vitro and in silico analyses of the bovine respiratory pathogen Pasteurella multocida, specifically the role of iron acquisition in bacterial virulence. The work resulted in a new model of the way in which iron availability influences the virulence of the bacteria in the bovine respiratory tract. Building on the theme of host-microbe interactions, my current work investigates the metabolic symbiosis between the pea aphid and its bacterial symbiont Buchnera. Exploiting an in silico metabolic model of the bacteria, we are currently building a model of the specialised aphid cells, the bacteriocytes, in which the bacteria are housed. Close collaboration with Angela Douglas' lab at Cornell University provides next generation sequence data, transcriptomic data, proteomic data and metabolic data to inform the model building.

Recent publications

  • Erratum: Intrinsic challenges in ancient microbiome reconstruction using 16S rRNA gene amplification (Scientific Reports (2016) 5 (16498) DOI: 10.1038/srep16498)

    • Ziesemer K
    • Mann A
    • Sankaranarayanan K
    • et al.
    N/AReaders
    0Citations
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  • Nitrogen recycling by metabolic pathways shared between an animal and its symbiotic bacteria: Waste not, want not

    • Macdonald S
    • Thomas G
    • Douglas A
    N/AReaders
    0Citations

Professional experience

Postdoctoral researcher

Department of Biology, University of York

March 2008 - Present

Education

Ph.D.

University of Edinburgh

October 2004 - June 2009(5 years)

B.Sc (Hons) Microbiology and Infection

University of Edinburgh

October 2000 - October 2004(4 years)

Groups

Co-authors (416)

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