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Scott Singleton

  • Ph.D.
  • Associate Professor
  • University of North Carolina at Chapel Hill
  • 25PublicationsNumber of items in Scott's My Publications folder on Mendeley.
  • 3Followers

Research interests

antibiotic resistancedrug discovery

About

Scott Singleton is an Associate Professor of Medicinal Chemistry & Natural Products in the School of Pharmacy at The University of North Carolina at Chapel Hill. Prior to his appointment to the faculty of UNC in 2003, Dr. Singleton was an Assistant Professor in the Departments of Chemistry and Biochemistry & Cell Biology at Rice University (1996-2003). Dr. Singleton’s areas of research interest lie at the interface of chemistry and biology, and his NIH-sponsored research program endeavors to understand the molecular basis for the evolution of drug resistance in pathogenic microorganisms. Seeking new opportunities for the development of integrated, multi-disciplinary knowledge and technologies, Dr. Singleton has led efforts to develop and adapt methods of organic chemistry and synthetic biology to provide new molecular tools - both biologically active small molecules and innovative platforms - for hypothesis-driven biological research and pharmaceutical discovery. Dr. Singleton is also an award-winning teacher of Organic Chemistry and Medicinal Chemistry for undergraduate, graduate, and professional students. Dr. Singleton holds B.A. degrees in Chemistry and Biology from Trinity University (San Antonio, TX) and a Ph.D. in Organic Chemistry from the California Institute of Technology. Following his doctoral research with Professor Peter B. Dervan at Caltech, Dr. Singleton was an NSF postdoctoral fellow with Professor Stephen J. Benkovic at Penn State

Followers (3)

Publications (5)

  • Direct evaluation of a kinetic model for RecA-mediated DNA-strand exchange: the importance of nucleic acid dynamics and entropy during homologous genetic recombination

    • Xiao J
    • Lee A
    • Singleton S
    N/AReaders
    N/ACitations
  • Inhibition of the Escherichia coli RecA protein: zinc(II), copper(II) and mercury(II) trap RecA as inactive aggregates

    • Lee A
    • Singleton S
    N/AReaders
    N/ACitations
  • Intein-mediated affinity-fusion purification of the Escherichia coli RecA protein

    • Singleton S
    • Simonette R
    • Sharma N
    • et al.
    N/AReaders
    N/ACitations
  • Molecular basis for nonadditive mutational effects in Escherichia coli dihydrofolate reductase

    • Wagner C
    • Huang Z
    • Singleton S
    • et al.
    N/AReaders
    N/ACitations
  • Temperature Dependence of the Energetics of Oligonucleotide-Directed Triple-Helix Formation at a Single DNA Site

    • Singleton S
    • Dervan P
    N/AReaders
    N/ACitations

Professional experience

Associate Professor

The University of North Carolina at Chapel Hill

July 2003 - Present

Assistant Professor

Rice University

July 1996 - June 2003(7 years)

NSF Postdoctoral Fellow

Pennsylvania State University

June 1994 - June 1996(2 years)

Education history

Ph.D.

California Institute of Technology

September 1988 - June 1994(6 years)

B.A.

Trinity University

August 1984 - May 1988(4 years)