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Seth Bordenstein

  • Ph.D. in Evolutionary Genetics
  • Assistant Professor
  • Vanderbilt University
  • 0ReadersNumber of instances of Seth's publications in Mendeley libraries. Updated daily.
  • 37PublicationsNumber of items in this person’s My Publications folder on Mendeley.

Research interests

NasoniaDrosophilaBacteriophageSequencingGenomicsMolecular EvolutionImmunityBacteriologyEcologyEvolutionMicrobiomeMicrobiotaMicrobiologyMobile DNASpeciationSymbiosis

About

Animals are superorganisms comprised of eukaryotic cells, bacterial symbionts, and viruses. Indeed, the genes in the symbiont population can vastly outnumber the genes of the animal host. However, we know little about the frequency at which these symbionts exchange genes via horizontal gene transfer nor the effects that the microbiota has on fundamental evolutionary processes including the origin of species. Our work has shown the even in the most restrictive class of symbionts, the obligate intracellular bacteria, there is a surprising amount of genetic flux between symbionts in the same host. We demonstrated that animals are frequently ecological arenas for gene transfer between intracellular infections (The Intracellular Arena Hypothesis) - thereby providing a means by which new genes and functions can be acquired by symbiotic bacteria. The discoveries of repeated gene transfers and phage activity between coinfections of animal intracellular bacteria specify fundamental roles for gene inflow in the evolution of intracellular bacteria. In addition, our current work on microbiota-host interactions specifies that the evolution of bacterial symbiont communities is fundamentally intertwined with the evolution of new host species, sometimes spurring the very reproductive isolation that causes host speciation.

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Following (18)

  • Daniel LePage

    Daniel LePage

  • Carl Zimmer

    Carl Zimmer

  • Jeff Jones

    Jeff JonesVanderbilt University

  • Jennifer Fogel

    Jennifer FogelUniversity of Georgia

  • Lisa Funkhouser

    Lisa FunkhouserVanderbilt University Department of Biological Sciences

  • Jon Erickson

    Jon EricksonVanderbilt University

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Publications (37)

In Vitro Cultivation of the Hymenoptera Genetic Model, Nasonia

  • Brucker R
  • Bordenstein S
PLoS ONE (2012)
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J-Western forms of Helicobacter pylori cagA constitute a distinct phylogenetic group with a widespread geographic distribution.

  • Duncan S
  • Valk P
  • Shaffer C
Journal Of Bacteriology (2012)
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The roles of host evolutionary relationships (genus: Nasonia) and development in structuring microbial communities

  • Brucker R
  • Bordenstein S
Evolution (2011)
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Symbiosis research, technology, and education: Proceedings of the 6th International Symbiosis Society Congress held in Madison Wisconsin, USA, August 2009

  • Goodrich-Blair H
  • Ane J
  • Bever J
Symbiosis (2010)
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Discovery of a novel Wolbachia supergroup in isoptera

  • Bordenstein S
  • Rosengaus R
Current Microbiology (2005)
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Professional experience

Assistant Professor

Vanderbilt University

August 2008 - Present

Education history

Ph.D. in Evolutionary Genetics

The University of Rochester

August 1997 - August 2002(5 years)

B.S. in Biological Sciences, Ecology and Evolutionary Biology

The University of Rochester

September 1993 - September 1997(4 years)