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Sophia Karagiannis

  • Reader in Translational Cancer Immunology, Head of Cancer Antibody Discovery and Immunother
  • King's College London
  • 21h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 1308CitationsNumber of citations received by Sophia's publications. Updated daily.

Other IDs

Research interests

Engineering of IgE class antibodies for cancerAntibody effector functionsB cell and antibody repertoires in solid tumoursB cell immunologyAntibody therapies for solid tumours

About

My laboratory is focused on designing and translating antibody therapies for solid tumours such as melanoma, ovarian and breast carcinomas. Our antibody discovery pathway is informed through dissecting the humoral immunity, investigating the tumour-targeting mechanisms of IgE class antibodies and Th2 responses in cancer and antibody Fc-mediated effector functions. Antibodies and B cell responses are examined as potential biomarkers, with a view of developing stratified medicine approaches and patient-focused treatments. We are presently developing a pipeline of antibodies and our first-in-class agent has reached a Phase I clinical trial.

Co-authors (261)

  • Rodolfo Bianchini
  • Alexander Koers
  • Barry Charlwood

Publications (5)

  • AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer

    • Jensen-Jarolim E
    • Bax H
    • Bianchini R
    • et al.
    N/AReaders
    3Citations
    Get full text
  • Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

    • Hoffmann R
    • Coumbe B
    • Josephs D
    • et al.
    N/AReaders
    2Citations
    Get full text
  • Engineering and stable production of recombinant IgE for cancer immunotherapy and AllergoOncology

    • Crescioli S
    • Chiaruttini G
    • Mele S
    • et al.
    N/AReaders
    0Citations
    Get full text
  • Evaluation of antigen-conjugated fluorescent beads to identify antigen-specific B cells

    • Correa I
    • Ilieva K
    • Crescioli S
    • et al.
    N/AReaders
    0Citations
    Get full text
  • Near infrared photoimmunotherapy targeting bladder cancer with a canine anti-epidermal growth factor receptor (EGFR) antibody

    • Nagaya T
    • Okuyama S
    • Ogata F
    • et al.
    N/AReaders
    0Citations
    Get full text

Editorships

ImmunoMedicine

Academic Editor

2018 - Present

BMC Cancer

Academic Editor

2015 - Present

ONCOLOGY REPORTS

Editorial Board

2014 - Present

PLOS One

Academic Editor

2011 - Present

Professional experience

Reader in Translational Cancer Immunology, Head of Cancer Antibody Discovery and Immunother

King's College London

September 2016 - Present

Senior Lecturer in Translational Cancer Immunology

King's College London

November 2013 - August 2016(3 years)

Education

PhD

King's College London

January 1991 - August 1994(4 years)