Stephen Henderson

  • Dr
  • Bioinformatics Researcher
  • UCL Cancer Institute

Research Interests

Machine Learning Genomics Data Mining Semantic Web Microarrays Cancer R Python Data Visualisation

Followers (19)

  • Ravindra Kumar

    Ravindra Kumar University of Delhi - South Campus

  • Mark Fortner

    Mark Fortner Aspen Biosciences

  • Denis Shestakov

    Denis Shestakov Aalto University, School of Science

  • Evgeny Denisov

    Evgeny Denisov Tomsk State University

  • chen jing

    chen jing

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Following (12)

  • Neha Ghevaria

    Neha Ghevaria

  • Christopher Yau

    Christopher Yau Wellcome Trust Centre for Human Genetics, University of Oxford

  • Richard Baird

    Richard Baird University of Cambridge

  • Daniel Brewer

    Daniel Brewer

  • Mingyu Liu

    Mingyu Liu Barclays Capital

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About

I am a bioinformatics researcher (systems biology if you like- I don't like this name) in the Viral Oncology group within the new(ish) UCL Cancer Institute. I am studying a lot of microarray, microRNA and sequencing data. I am mainly involved with Kaposi Sarcoma, Carcinoma of Unkown Primary (CUP), Head and Neck Tumour trial data-- and lots more....

I'm from Glasgow, Scotland- where I was an undergraduate, before moving to Cambridge to do a PhD with Simon Laughlin and Roger Hardie on the statistics, electrophysiology and genetics of the Drosphila (Fruit-Fly) eye.

Then I moved to London and worked in Parliament as a researcher, at Nature editing the website, and a few other jobs for a year or so.

I decided after that to change scientific direction and become a little less specialised so I took a Masters (MRes) course in Bioinformatics at Birkbeck College. This led to a position in the Viral Oncology group within the Wolfson Institute at UCL with Chris Boshoff. More recently our group has now moved to the newly opened UCL Cancer Institute and I have become a Cancer Research UK employed researcher.

Outside of work- I'm generally interested in computers, data mining, machine learning, Classics, Greek mythology, politics, jazz, techno, football, running, very loud parties and drinking-- in reverse order that is...

Publications

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

Nelson A, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple D, Stern C, Wardle F, Flanagan A

The Journal of pathology (2012)

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KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

Cheng F P

Cell Host Microbe (2011)

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DNA Methylome of Familial Breast Cancer Identifies Distinct Profiles Defined by Mutation Status.

Flanagan J, Cocciardi S, Waddell N, Johnstone C, Marsh A, Henderson S, Simpson P, da Silva L, Khanna K, Lakhani S, Boshoff C, Chenevix-Trench G

American journal of human genetics (2010)

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DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status.

Flanagan J, Kugler S, Waddell N, Johnstone C, Marsh A, Henderson S, Simpson P, da Silva L, Khanna K, Lakhani S, Boshoff C, Chenevix-Trench G

Breast cancer research : BCR (2010)

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KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Hansen A, Henderson S, Lagos D, Nikitenko L, Coulter E, Roberts S, Gratrix F, Plaisance K, Renne R, Bower M, Kellam P, Boshoff C

Genes & development (2010)

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Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.

Flutter B, Edwards N, Fallah-Arani F, Henderson S, Chai J, Sivakumaran S, Ghorashian S, Bennett C, Freeman G, Sykes M, Chakraverty R

The Journal of clinical investigation (2010)

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miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator

Lagos D, Pollara G, Henderson S, Gratrix F, Fabani M, Milne R, Gotch F, Boshoff C

Nature Cell Biology (2010)

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Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients.

Flanagan J, Munoz-Alegre M, Henderson S, Tang T, Sun P, Johnson N, Fletcher O, Dos Santos Silva I, Peto J, Boshoff C, Narod S, Petronis A

Human molecular genetics (2009)

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Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets.

Flanagan J, Funes J, Henderson S, Wild L, Carey N, Boshoff C

Molecular cancer therapeutics (2009)

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KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.

Emuss V, Lagos D, Pizzey A, Gratrix F, Henderson S, Boshoff C

PLoS pathogens (2009)

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The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens.

Robey R, Lagos D, Gratrix F, Henderson S, Matthews N, Vart R, Bower M, Boshoff C, Gotch F

PloS one (2009)

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Chondroblastomas but not chondromyxoid fibromas express cytokeratins: an unusual presentation of a chondroblastoma in the metaphyseal cortex of the tibia.

Bousdras K, O'Donnell P, Vujovic S, Henderson S, Boshoff C, Flanagan A

Histopathology (2007)

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Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation.

O'donnell P, Tirabosco R, Vujovic S, Bartlett W, Briggs T, Henderson S, Boshoff C, Flanagan A

Skeletal radiology (2007)

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Inhibition of gamma-secretases alters both proliferation and differentiation of mesenchymal stem cells.

Vujovic S, Henderson S, Flanagan A, Clements M

Cell proliferation (2007)

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Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production.

Funes J, Quintero M, Henderson S, Martinez D, Qureshi U, Westwood C, Clements M, Bourboulia D, Pedley R, Moncada S, Boshoff C

Proceedings of the National Academy of Sciences of the United States of America (2007)

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Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas.

Vujovic S, Henderson S, Presneau N, Odell E, Jacques T, Tirabosco R, Boshoff C, Flanagan A

The Journal of pathology (2006)

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A molecular map of mesenchymal tumors.

Henderson S, Guiliano D, Presneau N, McLean S, Frow R, Vujovic S, Anderson J, Sebire N, Whelan J, Athanasou N, Flanagan A, Boshoff C

Genome biology (2005)

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Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

Laman H, Funes J, Ye H, Henderson S, Galinanes-Garcia L, Hara E, Knowles P, McDonald N, Boshoff C

The EMBO journal (2005)

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Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.

Wang H, Trotter M, Lagos D, Bourboulia D, Henderson S, Mäkinen T, Elliman S, Flanagan A, Alitalo K, Boshoff C

Nature genetics (2004)

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Predicting biomarkers for ovarian cancer using gene-expression microarrays.

Adib T, Henderson S, Perrett C, Hewitt D, Bourmpoulia D, Ledermann J, Boshoff C

British journal of cancer (2004)

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Gene expression array profile of human osteosarcoma.

Leonard P, Sharp T, Henderson S, Hewitt D, Pringle J, Sandison A, Goodship A, Whelan J, Boshoff C

British journal of cancer (2003)

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Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopes.

Stebbing J, Bourboulia D, Johnson M, Henderson S, Williams I, Wilder N, Tyrer M, Youle M, Imami N, Kobu T, Kuon W, Sieper J, Gotch F, Boshoff C

Journal of virology (2003)

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Single photon responses in Drosophila photoreceptors and their regulation by Ca2+.

Henderson S, Reuss H, Hardie R

The Journal of physiology (2000)

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Differential effects of ninaC proteins (p132 and p174) on light-activated currents and pupil mechanism in Drosophila photoreceptors.

Hofstee C, Henderson S, Hardie R, Stavenga D

Visual neuroscience

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Professional experience

Bioinformatics Researcher

UCL Cancer Institute

October 2002 - Present

Education history

Birkbeck College, University of London

MRes Bioinformatics

October 2000 - June 2001 (8 months)

University of Cambridge

PhD (Zoology Dept, Anatomy Dept)

October 1994 - June 1998 (3 years 8 months)

University of Glasgow

BSc Cell Biology

October 1990 - June 1994 (3 years 8 months)