An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.
The Journal of pathology (2012)
KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.
Cell Host Microbe (2011)
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.
The Journal of clinical investigation (2010)
DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status.
Breast cancer research : BCR (2010)
KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.
Genes & development (2010)
miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator
Nature Cell Biology (2010)
DNA Methylome of Familial Breast Cancer Identifies Distinct Profiles Defined by Mutation Status.
American journal of human genetics (2010)
Differential effects of ninaC proteins (p132 and p174) on light-activated currents and pupil mechanism in Drosophila photoreceptors.
Single photon responses in Drosophila photoreceptors and their regulation by Ca2+.
The Journal of physiology (2000)
Inhibition of gamma-secretases alters both proliferation and differentiation of mesenchymal stem cells.
Cell proliferation (2007)
Gene expression array profile of human osteosarcoma.
British journal of cancer (2003)
Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopes.
Journal of virology (2003)
Predicting biomarkers for ovarian cancer using gene-expression microarrays.
British journal of cancer (2004)
Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.
The EMBO journal (2005)
Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas.
The Journal of pathology (2006)
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.
Nature genetics (2004)
A molecular map of mesenchymal tumors.
Genome biology (2005)
Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation.
Skeletal radiology (2007)
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production.
Proceedings of the National Academy of Sciences of the United States of America (2007)
Chondroblastomas but not chondromyxoid fibromas express cytokeratins: an unusual presentation of a chondroblastoma in the metaphyseal cortex of the tibia.
Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets.
Molecular cancer therapeutics (2009)
Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients.
Human molecular genetics (2009)
The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens.
PloS one (2009)
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.
PLoS pathogens (2009)
UCL Cancer Institute
October 2002 - Present
Birkbeck College, University of London
October 2000 - June 2001 (8 months)
University of Cambridge
PhD (Zoology Dept, Anatomy Dept)
October 1994 - June 1998 (3 years 8 months)
University of Glasgow
BSc Cell Biology
October 1990 - June 1994 (3 years 8 months)