Stephen Henderson Dr

Bioinformatics Researcher

UCL Cancer Institute

Location
London, United Kingdom
Discipline
Biological Sciences
Interests
Machine Learning, Genomics, Data Mining, Semantic Web, Microarrays, Cancer, R, Python, Data Visualisation
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Followers (19)

  • Richard Baird

    Richard Baird Cambridge University Hospitals NHS Trust

  • Mingyu Liu

    Mingyu Liu Barclays Capital

  • Christopher Yau

    Christopher Yau Wellcome Trust Centre for Human Genetics, University of Oxford

  • Rayna St

    Rayna St LMU / TUM MUNICH

  • Sukhbir Rattan

    Sukhbir Rattan Institute of Genomics and Integrative Biology

Following (12)

  • Laure Duhamel

    Laure Duhamel

  • Daniel Brewer

    Daniel Brewer

  • Richard Baird

    Richard Baird Cambridge University Hospitals NHS Trust

  • Mingyu Liu

    Mingyu Liu Barclays Capital

  • Christopher Yau

    Christopher Yau Wellcome Trust Centre for Human Genetics, University of Oxford

About

I am a bioinformatics researcher (systems biology if you like- I don't like this name) in the Viral Oncology group within the new(ish) UCL Cancer Institute. I am studying a lot of microarray, microRNA and sequencing data. I am mainly involved with Kaposi Sarcoma, Carcinoma of Unkown Primary (CUP), Head and Neck Tumour trial data-- and lots more....

I'm from Glasgow, Scotland- where I was an undergraduate, before moving to Cambridge to do a PhD with Simon Laughlin and Roger Hardie on the statistics, electrophysiology and genetics of the Drosphila (Fruit-Fly) eye.

Then I moved to London and worked in Parliament as a researcher, at Nature editing the website, and a few other jobs for a year or so.

I decided after that to change scientific direction and become a little less specialised so I took a Masters (MRes) course in Bioinformatics at Birkbeck College. This led to a position in the Viral Oncology group within the Wolfson Institute at UCL with Chris Boshoff. More recently our group has now moved to the newly opened UCL Cancer Institute and I have become a Cancer Research UK employed researcher.

Outside of work- I'm generally interested in computers, data mining, machine learning, Classics, Greek mythology, politics, jazz, techno, football, running, very loud parties and drinking-- in reverse order that is...
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Publications

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

Nelson A, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D et al.

The Journal of pathology (2012)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

Cheng F P

Cell Host Microbe (2011)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.

Flutter B, Edwards N, Fallah-Arani F, Henderson S, Chai J, Sivakumaran S et al.

The Journal of clinical investigation (2010)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status.

Flanagan J, Kugler S, Waddell N, Johnstone C, Marsh A, Henderson S et al.

Breast cancer research : BCR (2010)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Hansen A, Henderson S, Lagos D, Nikitenko L, Coulter E, Roberts S et al.

Genes & development (2010)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator

Lagos D, Pollara G, Henderson S, Gratrix F, Fabani M, Milne R et al.

Nature Cell Biology (2010)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

DNA Methylome of Familial Breast Cancer Identifies Distinct Profiles Defined by Mutation Status.

Flanagan J, Cocciardi S, Waddell N, Johnstone C, Marsh A, Henderson S et al.

American journal of human genetics (2010)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Differential effects of ninaC proteins (p132 and p174) on light-activated currents and pupil mechanism in Drosophila photoreceptors.

Hofstee C, Henderson S, Hardie R, Stavenga D

Visual neuroscience

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Single photon responses in Drosophila photoreceptors and their regulation by Ca2+.

Henderson S, Reuss H, Hardie R

The Journal of physiology (2000)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Inhibition of gamma-secretases alters both proliferation and differentiation of mesenchymal stem cells.

Vujovic S, Henderson S, Flanagan A, Clements M

Cell proliferation (2007)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Gene expression array profile of human osteosarcoma.

Leonard P, Sharp T, Henderson S, Hewitt D, Pringle J, Sandison A et al.

British journal of cancer (2003)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Kaposi's sarcoma-associated herpesvirus cytotoxic T lymphocytes recognize and target Darwinian positively selected autologous K1 epitopes.

Stebbing J, Bourboulia D, Johnson M, Henderson S, Williams I, Wilder N et al.

Journal of virology (2003)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Predicting biomarkers for ovarian cancer using gene-expression microarrays.

Adib T, Henderson S, Perrett C, Hewitt D, Bourmpoulia D, Ledermann J et al.

British journal of cancer (2004)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

Laman H, Funes J, Ye H, Henderson S, Galinanes-Garcia L, Hara E et al.

The EMBO journal (2005)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas.

Vujovic S, Henderson S, Presneau N, Odell E, Jacques T, Tirabosco R et al.

The Journal of pathology (2006)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.

Wang H, Trotter M, Lagos D, Bourboulia D, Henderson S, Mäkinen T et al.

Nature genetics (2004)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

A molecular map of mesenchymal tumors.

Henderson S, Guiliano D, Presneau N, McLean S, Frow R, Vujovic S et al.

Genome biology (2005)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation.

O'donnell P, Tirabosco R, Vujovic S, Bartlett W, Briggs T, Henderson S et al.

Skeletal radiology (2007)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production.

Funes J, Quintero M, Henderson S, Martinez D, Qureshi U, Westwood C et al.

Proceedings of the National Academy of Sciences of the United States of America (2007)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Chondroblastomas but not chondromyxoid fibromas express cytokeratins: an unusual presentation of a chondroblastoma in the metaphyseal cortex of the tibia.

Bousdras K, O'Donnell P, Vujovic S, Henderson S, Boshoff C, Flanagan A

Histopathology (2007)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets.

Flanagan J, Funes J, Henderson S, Wild L, Carey N, Boshoff C

Molecular cancer therapeutics (2009)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients.

Flanagan J, Munoz-Alegre M, Henderson S, Tang T, Sun P, Johnson N et al.

Human molecular genetics (2009)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens.

Robey R, Lagos D, Gratrix F, Henderson S, Matthews N, Vart R et al.

PloS one (2009)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.

Emuss V, Lagos D, Pizzey A, Gratrix F, Henderson S, Boshoff C

PLoS pathogens (2009)

  • -- Readers Readers not available. This publication is not currently accessible in the Mendeley catalog.

Professional experience

Bioinformatics Researcher

UCL Cancer Institute

October 2002 - Present

Education history

Birkbeck College, University of London

MRes Bioinformatics

October 2000 - June 2001 (8 months)

University of Cambridge

PhD (Zoology Dept, Anatomy Dept)

October 1994 - June 1998 (3 years 8 months)

University of Glasgow

BSc Cell Biology

October 1990 - June 1994 (3 years 8 months)