I am currently pursuing an Integrated PhD in Neuroscience at National Brain Research Centre (http://www.nbrc.ac.in/)
My current field of work is a neurodevelopmental disorder called Angelman Syndrome. I use both cell culture system and Ube3a knockout mouse model (behavioral and molecular studies), to understand the role of the candidate gene-UBE3A-in the pathogenesis of this disease. Understanding the molecular pathogenesis of neurodevelopmental and autism spectrum disorders especially at synaptic level, is where my current interest lies.
My main interest lies in the area of neurodevelopment. The self-organisation of brain into functional circuits, mechanisms mediating the targeting of the appropriate synaptic partners and how external stimuli play an important role in shaping these circuits; these are questions that greatly interest me. The intriguing aspect of some types of autism spectrum disorders, as is also seen in AS is the abnormal functional connectivity. Thus, in the future, using such model systems, I would like to address the question of how neurons specify and control the number of connections that they form. Also, how the interplay between inhibitory and excitatory neurons, during development in an experience dependent manner, aids in shaping the brain circuitry. However, I am open to new avenues and ideas.