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Swetha Godavarthi

  • Graduate Student
  • Senior Research Fellow
  • National Brain Research Centre
  • 4PublicationsNumber of items in Swetha's My Publications folder on Mendeley.
  • 18Followers

Research interests

Synaptic plasticityAutismNeurogenesisNeurodegenerationMolecular BiologyRegeneration

About

I am currently pursuing an Integrated PhD in Neuroscience at National Brain Research Centre (http://www.nbrc.ac.in/) My current field of work is a neurodevelopmental disorder called Angelman Syndrome. I use both cell culture system and Ube3a knockout mouse model (behavioral and molecular studies), to understand the role of the candidate gene-UBE3A-in the pathogenesis of this disease. Understanding the molecular pathogenesis of neurodevelopmental and autism spectrum disorders especially at synaptic level, is where my current interest lies. My main interest lies in the area of neurodevelopment. The self-organisation of brain into functional circuits, mechanisms mediating the targeting of the appropriate synaptic partners and how external stimuli play an important role in shaping these circuits; these are questions that greatly interest me. The intriguing aspect of some types of autism spectrum disorders, as is also seen in AS is the abnormal functional connectivity. Thus, in the future, using such model systems, I would like to address the question of how neurons specify and control the number of connections that they form. Also, how the interplay between inhibitory and excitatory neurons, during development in an experience dependent manner, aids in shaping the brain circuitry. However, I am open to new avenues and ideas.

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Publications (4)

  • Dysfunction of the ubiquitin ligase Ube3a may be associated with synaptic pathophysiology in a mouse model of Huntington disease.

    • Maheshwari M
    • Samanta A
    • Godavarthi S
    • et al.
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  • Induction of chemokines, MCP-1, and KC in the mutant huntingtin expressing neuronal cells because of proteasomal dysfunction.

    • Godavarthi S
    • Narender D
    • Mishra A
    • et al.
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    N/ACitations
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  • The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins.

    • Mishra A
    • Godavarthi S
    • Maheshwari M
    • et al.
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  • UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27.

    • Mishra A
    • Godavarthi S
    • Jana N
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    N/ACitations
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Professional experience

Senior Research Fellow

National Brain Research Centre

Education

Int PhD

National Brain Research Centre

Bsc(Hons) Biochemistry

University of Delhi