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Tim Morris

  • BEng AMIChemE KS
  • Research Student
  • Loughborough University
  • 2PublicationsNumber of items in Tim's My Publications folder on Mendeley.
  • 23Followers

About

Hi, I'm Tim. Like most people my age, I'm 22. As part of the first year of the DTC's 3rd Cohort, I am currently in the midst of my 3rd miniproject, and as of yet do not have a full PhD title, what follows is information related to a business based literature review I did last Autumn, and my first mini-project which was completed in late March of this year. Literature Review: Reimbursing cures? Supervisor: Prof. David Williams Institution: Wolfson School, Loughborough University Abstract: A model is proposed for the reimbursement of regenerative medicine and medical device “cures”. The pharmaceutical model is not currently set out to allow sensible and fair pricing for such products. The model is based on a favourable proportion of the whole life costs of a drug. The model has three factors which must be discussed- silo budgeting, budget busting and the established models for reimbursing pharmaceuticals and medical devices. To develop the model and investigate the paradigms, the healthcare delivery systems of the Commonwealth nations (UK, Australia, Canada and New Zealand), the Nordic countries and the United States were investigated. A comprehensive diagram was drawn up summarising the findings. In the research it was revealed that NICE, part of the British healthcare system was regarded as the favoured market for health technology introductions, reasons for this were speculated upon. An alternative of our model was discussed based on findings by Bach and Pearson, and its possibility for introduction discussed. Finally it was determined that a simple proportionality term could not be determined and a method to define it is needed. We suggest using the EVIDEM framework; this would be based on patient conditions, indication and location. Whilst the model requires further specification, it’s research and development has now been more clearly defined. Mini-Project I: Improving the corneal bioreactor. Supervisors: Dr. Ying Yang and Prof. Alicia El Haj Institution: ISTM, Keele University Abstract: A series of techniques were used to investigate improving the corneal bioreactor. Cell Culture was used to culture primary porcine cornea samples with images taken after 5 days showing proliferated cells. The Bowman’s layer was mimicked using Rat Tail collagen I. To test the permeability of the collagen with respect to proteins, Bovine Serum Albumin was added to the top of collagen gels in a steel bioreactor construct at different densities (2.5, 3.5 and 4.5mg/ml), samples from the bottom were taken and analysed using UV spectroscopy. Results showed that the densest collagen is less permeable by almost two orders of magnitude compared to the least dense collagen. A virtual prototype of an improved bioreactor design was drawn up and described. This design has more commercial potential than those previously shown in literature. Dates: 17 January – 18 March Mini-Project II: Mechanical Testing of Super Critical CO2 foamed scaffolds Supervisor: Prof. Steve Howdle Institution: School of Chemistry/School of Pharmacy, The University of Nottingham Abstract: Supercritical fluids are used to create porous scaffolds for use in hip implant revision arthroplasty. Recent data has indicated that the polymer type, polymer molecular weight and the addition of a hydroxyapatite mineral component has a dramatic effect upon the mechanical properties of the scaffolds and this influences their performance in vivo. The aim of this project is to assess a range of polymers and hydroxyapatite contents to determine the effect upon the supercritical foaming process (i.e. porosity) and subsequent mechanical properties. Dates: 28 March – 3 June Mini-Project III: Microgravity Testing within the NASA/JSC RWPV Bioreactor Supervisors: Dr. Diganta Das and Prof. Chris Hewitt Institution: Department of Chemical Engineering, Loughborough University Abstract: The National Aeronautics and Space Administration (NASA), USA, has developed a rotating, cylindrical bioreactor that can be used on the earth as well as in the space. The bioreactor was originally invented by the NASA as a model of microgravity effects on cells. However its potential for contributions is many (e.g., growing artificial bone tissue) and, this is an extremely good tool to understand specific mechanisms that affect tissue growth, e.g., cell-cell interactions, cell-scaffold interactions without having to worry about other secondary effects, such as gravity. It has been argued that this bioreactor can be used to grow 3D tissues without scaffold provided the optimum operating conditions are identified. The aim of this mini-project is to learn how to operate the NASA bioreactor and test the above hypothesis by conducting well defined experiments of cell culture using the bioreactor. In particular, the project should aim to identify under what condition the cells grow to make 3D structure (3D tissues) without scaffold, if possible. Dates: 13 June – 5 August

Research interests

Recent publications

  • Improving the corneal bioreactor: cell culture, mimicking the Bowman's Layer and virtual prototyping

    • Morris T
    N/AReaders
    N/ACitations
  • Reimbursing cures?

    • Morris T
    • McCall M
    • Williams D
    N/AReaders
    N/ACitations

Professional experience

Research Student

Loughborough University

October 2010 - Present

Student Process Engineer

Avecia Biologics, Ltd

August 2008 - July 2009(a year)

Education

PhD

EPSRC DTC Regenerative Medicine

October 2010 - Present

BEng Chemical Engineering with Environmental Protection

Loughborough University

September 2006 - June 2010(4 years)

Groups

Followers (23)

Explore network

Following (24)