13C editing of glutamate in human brain using J-refocused coherence transfer spectroscopy at 4.1 T

  • Pan J
  • Mason G
  • Vaughan J
 et al. 
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Abstract

The method of single quantum C-13 editing is analyzed and implemented with water suppressed J-refocused coherence transfer spectroscopy. Analysis of the C-13 inversion pulse demonstrates that it is optimally placed into the second echo of the J-refocused sequence. We have used this method to acquire C-13-edited spectra of glutamate from phantoms and in vivo. The turnover of (13)C4-labeled glutamate in human brain in vivo was observed in parasagittal gray matter using a volume head coil at 4.1 T with a time resolution of 5.3 min.

Author-supplied keywords

  • 13C
  • brain metabolism
  • coherence transfer spectroscopy
  • glutamate

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Authors

  • Jullie W. Pan

  • Graeme F. Mason

  • J. Thomas Vaughan

  • Wen Jang Chu

  • Yantian Zhang

  • Hoby P. Hetherington

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