The method of single quantum C-13 editing is analyzed and implemented with water suppressed J-refocused coherence transfer spectroscopy. Analysis of the C-13 inversion pulse demonstrates that it is optimally placed into the second echo of the J-refocused sequence. We have used this method to acquire C-13-edited spectra of glutamate from phantoms and in vivo. The turnover of (13)C4-labeled glutamate in human brain in vivo was observed in parasagittal gray matter using a volume head coil at 4.1 T with a time resolution of 5.3 min.
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