The 5-HT1A receptor knockout mouse and anxiety.

  • Olivier B
  • Pattij T
  • Wood S
 et al. 
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The 5-HT1A receptor has been implicated in the modulation of anxiety processes, mainly via pharmacological experiments. The recent production, in 3 independent research groups, of 5-HT1A receptor knockout (R KO) mice in 3 different genetic backgrounds (C57BL/6j, 129/Sv, Swiss-Webster) led to the intriguing finding that all mice, independent from the genetic background strain from which the null mutants were made, showed an 'anxious' phenotype compared to corresponding wild-type mice. The present paper reviews the behavioral findings in these 3 KO lines and focuses on new findings in the 129/Sv-KO mice. These mice were more anxious or stress-prone only under specific conditions and not as broadly as suggested from the initial studies. The 5-HT1A R KO made in the Swiss-Webster background displays disturbances in the GABAA-benzodiazepine (BZ) receptor system in the brain, including downregulation of GABAA αl and α2 subunits in the amygdala. In contrast, the GABAA-BZ receptor system seems to function normally in the 5-HT1a R KO in the 129/Sv background suggesting that changes in the GABAA-BZ receptor system may not be a prerequisite for anxiety but rather could have a modifying effect on this phenotype. (PsycINFO Database Record (c) 2016 APA, all rights reserved)

Author-supplied keywords

  • 2001
  • Animal Strain Differences
  • Anxiety
  • Genetics
  • Mice
  • Mutations
  • Neural Receptors
  • Phenotypes
  • Serotonin
  • anxiety
  • genetic background
  • phenotypes
  • serotonin receptor knockout mice
  • serotonin receptors

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  • Berend Olivier

  • T Pattij

  • S J Wood

  • R Oosting

  • Z Sarnyai

  • M Toth

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