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Obesity-associated variants within FTO form long-range functional connections with IRX3

Smemo S, Tena J, Kim K, Gamazon E, Sakabe N, Gómez-Marín C, Aneas I, Credidio F, Sobreira D, Wasserman N, Lee J, Puviindran V, Tam D, Shen M, Son J, Vakili N, Sung H, Naranjo S, Acemel R, Manzanares M, Nagy A, Cox N, Hui C, Gomez-Skarmeta J, Nóbrega M ...see all

Nature, vol. 507, issue 7492 (2014) pp. 371-375

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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang Y, He C ...see all

Nature Chemical Biology, vol. 7, issue 12 (2011) pp. 885-887 Published by Nature Publishing Group

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The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

Gerken T, Girard C, Tung Y, Webby C, Saudek V, Hewitson K, Yeo G, McDonough M, Cunliffe S, McNeill L, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll A, Ma M, Jovanovic Z, Farooqi I, Sedgwick B, Barroso I, Lindahl T, Ponting C, Ashcroft F, O'Rahilly S, Schofield C ...see all

Science, vol. 318, issue 5855 (2007) pp. 1469-1472

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The genetics of obesity: FTO leads the way

Fawcett K, Barroso I ...see all

Trends in Genetics, vol. 26, issue 6 (2010) pp. 266-274

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Overexpression of Fto leads to increased food intake and results in obesity

Church C, Moir L, McMurray F, Girard C, Banks G, Teboul L, Wells S, Brüning J, Nolan P, Ashcroft F, Cox R ...see all

Nature Genetics, vol. 42, issue 12 (2010) pp. 1086-1092

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Inactivation of the Fto gene protects from obesity

Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning J, Rüther U ...see all

Nature, vol. 458, issue 7240 (2009) pp. 894-898

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A link between FTO, ghrelin, and impaired brain food-cue responsivity

Karra E, O'Daly O, Choudhury A, Yousseif A, Millership S, Neary M, Scott W, Chandarana K, Manning S, Hess M, Iwakura H, Akamizu T, Millet Q, Gelegen C, Drew M, Rahman S, Emmanuel J, Williams S, Rüther U, Brüning J, Withers D, Zelaya F, Batterham R ...see all

Journal of Clinical Investigation, vol. 123, issue 8 (2013) pp. 3539-3551

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The bigger picture of FTO - The first GWAS-identified obesity gene

Loos R, Yeo G ...see all

Nature Reviews Endocrinology, vol. 10, issue 1 (2014) pp. 51-61

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Commentary: FTO obesity variant circuitry and adipocyte browning in humans

Laber S, Cox R ...see all

Frontiers in Genetics, vol. 6, issue OCT (2015) Published by Frontiers Research Foundation

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Crystal structure of the FTO protein reveals basis for its substrate specificity

Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J ...see all

Nature, vol. 464, issue 7292 (2010) pp. 1205-1209

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FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

Zhao X, Yang Y, Sun B, Shi Y, Yang X, Xiao W, Hao Y, Ping X, Chen Y, Wang W, Jin K, Wang X, Huang C, Fu Y, Ge X, Song S, Jeong H, Yanagisawa H, Niu Y, Jia G, Wu W, Tong W, Okamoto A, He C, Danielsen J, Wang X, Yang Y ...see all

Cell Research, vol. 24, issue 12 (2014) pp. 1403-1419 Published by Nature Publishing Group

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Obesity associated genetic variation in FTO is associated with diminished satiety

Wardle J, Carnell S, Haworth C, Farooqi I, O'Rahilly S, Plomin R ...see all

Journal of Clinical Endocrinology and Metabolism, vol. 93, issue 9 (2008) pp. 3640-3643 Published by Endocrine Society

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Role for the obesity-related FTO gene in the cellular sensing of amino acids

Gulati P, Cheung M, Antrobus R, Church C, Harding H, Tung Y, Rimmington D, Ma M, Ron D, Lehner P, Ashcroft F, Cox R, Coll A, O'Rahilly S, Yeo G ...see all

Proceedings of the National Academy of Sciences, vol. 110, issue 7 (2013) pp. 2557-2562

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Network Medicine — From Obesity to the “Diseasome”

Barabási A ...see all

New England Journal of Medicine, vol. 357, issue 4 (2007) pp. 404-407

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Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children

Kilpeläinen T, Qi L, Brage S, Sharp S, Sonestedt E, Demerath E, Ahmad T, Mora S, Kaakinen M, Sandholt C, Holzapfel C, Autenrieth C, Hyppönen E, Cauchi S, He M, Kutalik Z, Kumari M, Stančáková A, Meidtner K, Balkau B, Tan J, Mangino M, Timpson N, Song Y, Zillikens M, Jablonski K, Garcia M, Johansson S, Bragg-Gresham J, Wu Y, van Vliet-Ostaptchouk J, Onland-Moret N, Zimmermann E, Rivera N, Tanaka T, Stringham H, Silbernagel G, Kanoni S, Feitosa M, Snitker S, Ruiz J, Metter J, Larrad M, Atalay M, Hakanen M, Amin N, Cavalcanti-Proença C, Grøntved A, Hallmans G, Jansson J, Kuusisto J, Kähönen M, Lutsey P, Nolan J, Palla L, Pedersen O, Pérusse L, Renström F, Scott R, Shungin D, Sovio U, Tammelin T, Rönnemaa T, Lakka T, Uusitupa M, Rios M, Ferrucci L, Bouchard C, Meirhaeghe A, Fu M, Walker M, Borecki I, Dedoussis G, Fritsche A, Ohlsson C, Boehnke M, Bandinelli S, van Duijn C, Ebrahim S, Lawlor D, Gudnason V, Harris T, Sørensen T, Mohlke K, Hofman A, Uitterlinden A, Tuomilehto J, Lehtimäki T, Raitakari O, Isomaa B, Njølstad P, Florez J, Liu S, Ness A, Spector T, Tai E, Froguel P, Boeing H, Laakso M, Marmot M, Bergmann S, Power C, Khaw K, Chasman D, Ridker P, Hansen T, Monda K, Illig T, Järvelin M, Wareham N, Hu F, Groop L, Orho-Melander M, Ekelund U, Franks P, Loos R ...see all

PLoS Medicine, vol. 8, issue 11 (2011) Published by Public Library of Science

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A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

Church C, Lee S, Bagg E, McTaggart J, Deacon R, Gerken T, Lee A, Moir L, Mecinović J, Quwailid M, Schofield C, Ashcroft F, Cox R ...see all

PLoS Genetics, vol. 5, issue 8 (2009)

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FTO genotype is associated with phenotypic variability of body mass index

Yang J, Loos R, Powell J, Medland S, Speliotes E, Chasman D, Rose L, Thorleifsson G, Steinthorsdottir V, Mägi R, Waite L, Vernon Smith A, Yerges-Armstrong L, Monda K, Hadley D, Mahajan A, Li G, Kapur K, Vitart V, Huffman J, Wang S, Palmer C, Esko T, Fischer K, Hua Zhao J, Demirkan A, Isaacs A, Feitosa M, Luan J, Heard-Costa N, White C, Jackson A, Preuss M, Ziegler A, Eriksson J, Kutalik Z, Frau F, Nolte I, Van Vliet-Ostaptchouk J, Hottenga J, Jacobs K, Verweij N, Goel A, Medina-Gomez C, Estrada K, Bragg-Gresham J, Sanna S, Sidore C, Tyrer J, Teumer A, Prokopenko I, Mangino M, Lindgren C, Assimes T, Shuldiner A, Hui J, Beilby J, McArdle W, Hall P, Haritunians T, Zgaga L, Kolcic I, Polasek O, Zemunik T, Oostra B, Juhani Junttila M, Grönberg H, Schreiber S, Peters A, Hicks A, Stephens J, Foad N, Laitinen J, Pouta A, Kaakinen M, Willemsen G, Vink J, Wild S, Navis G, Asselbergs F, Homuth G, John U, Iribarren C, Harris T, Launer L, Gudnason V, O'Connell J, Boerwinkle E, Cadby G, Palmer L, James A, Musk A, Ingelsson E, Psaty B, Beckmann J, Waeber G, Vollenweider P, Hayward C, Wright A, Rudan I, Groop L, Metspalu A, Tee Khaw K, Van Duijn C, Borecki I, Province M, Wareham N, Tardif J, Huikuri H, Adrienne Cupples L, Atwood L, Fox C, Boehnke M, Collins F, Mohlke K, Erdmann J, Schunkert H, Hengstenberg C, Stark K, Lorentzon M, Ohlsson C, Cusi D, Staessen J, Van Der Klauw M, Pramstaller P, Kathiresan S, Jolley J, Ripatti S, Jarvelin M, De Geus E, Boomsma D, Penninx B, Wilson J, Campbell H, Chanock S, Van Der Harst P, Hamsten A, Watkins H, Hofman A, Witteman J, Carola Zillikens M, Uitterlinden A, Rivadeneira F, Carola Zillikens M, Kiemeney L, Vermeulen S, Abecasis G, Schlessinger D, Schipf S, Stumvoll M, Tönjes A, Spector T, North K, Lettre G, McCarthy M, Berndt S, Heath A, Madden P, Nyholt D, Montgomery G, Martin N, McKnight B, Strachan D, Hill W, Snieder H, Ridker P, Thorsteinsdottir U, Stefansson K, Frayling T, Hirschhorn J, Goddard M, Visscher P ...see all

Nature, vol. 490, issue 7419 (2012) pp. 267-273

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Variation in FTO contributes to childhood obesity and severe adult obesity

Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, Carlsson L, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougnères P, Kovacs P, Marre M, Balkau B, Cauchi S, Chèvre J, Froguel P ...see all

Nature Genetics, vol. 39, issue 6 (2007) pp. 724-726

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Growth of oriented single-crystalline rutile TiO 2 nanorods on transparent conducting substrates for dye-sensitized solar cells

Liu B, Aydil E ...see all

Journal of the American Chemical Society, vol. 131, issue 11 (2009) pp. 3985-3990

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Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats

Tung Y, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll A, Yeo G ...see all

PLoS ONE, vol. 5, issue 1 (2010)

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