(AAT)n repeat in the cannabinoid receptor gene (CNR1): Association with cocaine addiction in an African-Caribbean population

  • Ballon N
  • Leroy S
  • Roy C
 et al. 
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Abstract

Owing to their agonist action on dopaminergic systems, cannabinoids may play a major role in substance dependency and schizophrenia. We examined the (AAT)n triplet repeat polymorphism nearby the CNR1 gene, which encodes human cannabinoid (CB1) receptor, in a male Afro-Caribbean population. The allelic and genotypic distributions were significantly different in non-schizophrenic cocaine dependents (n = 97), schizophrenic cocaine dependents (n = 45) and matched controls (n = 88) (P < 10(-4)). The frequency of the (AAT)12 repeat allele was increased in non-schizophrenic cocaine dependents and schizophrenic cocaine dependents vs controls (25.3 and 26.7 vs 5.7%) (P < 10(-4)). Our results support that the (AAT)n polymorphism nearby the CNR1 gene could be associated with predisposition to cocaine dependency.

Author-supplied keywords

  • Cannabis
  • Crack cocaine
  • Genetics
  • Schizophrenia
  • Substances abuse
  • West Indies

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Authors

  • N. Ballon

  • S. Leroy

  • C. Roy

  • M. C. Bourdel

  • A. Charles-Nicolas

  • M. O. Krebs

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