The ABCs of Immunology: Structure and Function of TAP, the Transporter Associated with Antigen Processing

  • Abele R
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Abstract

The transporter associated with antigen processing {(TAP)} is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum {(ER),} where these peptides are loaded on major histocompatibility complex {(MHC)} I molecules. Loaded {MHC} I leave the {ER} and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. Here we discuss the structure, function, and mechanism of {TAP} as a central part of the peptide-loading complex. Furthermore, aspects of virus and tumor escape strategies are presented.

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Authors

  • R. Abele

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