The ABCs of Immunology: Structure and Function of TAP, the Transporter Associated with Antigen Processing

  • Abele R
  • 72


    Mendeley users who have this article in their library.
  • 114


    Citations of this article.


The transporter associated with antigen processing {(TAP)} is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum {(ER),} where these peptides are loaded on major histocompatibility complex {(MHC)} I molecules. Loaded {MHC} I leave the {ER} and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. Here we discuss the structure, function, and mechanism of {TAP} as a central part of the peptide-loading complex. Furthermore, aspects of virus and tumor escape strategies are presented.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • R. Abele

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free