Abdominal adiposity and the polycystic ovary syndrome

  • Escobar-Morreale H
  • Millán J
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Abstract

Abdominal adiposity, overweightness and obesity are frequently present in patients with polycystic ovary syndrome (PCOS). A large body of evidence suggests that abdominal adiposity and the resulting insulin resistance contribute to ovarian and, possibly, adrenal hyperandrogenism. However, androgen excess itself might also contribute to abdominal fat deposition in hyperandrogenic women. Recent genomic and proteomic analyses of visceral fat from PCOS patients have detected differences in gene expression and protein content compared with those of non-hyperandrogenic women. Here we review the existing evidence for a vicious circle whereby androgen excess favoring the abdominal deposition of fat further facilitates androgen secretion by the ovaries and adrenals in PCOS patients. © 2007 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • abdominal obesity
  • adipose tissue
  • adrenal gland
  • androgen
  • androgen release
  • androgen synthesis
  • bariatric surgery
  • clinical trial
  • combination chemotherapy
  • diet therapy
  • flutamide
  • gonadorelin agonist
  • human
  • hyperandrogenism
  • hyperinsulinemia
  • insulin
  • insulin resistance
  • insulin sensitizing agent
  • intraabdominal fat
  • leptin
  • lifestyle modification
  • lipid storage
  • low drug dose
  • metformin
  • nonhuman
  • obesity
  • ovariectomy
  • ovary polycystic disease
  • prevalence
  • priority journal
  • review
  • sibutramine
  • steroidogenesis
  • testosterone
  • tetrahydrolipstatin
  • tumor necrosis factor alpha
  • weight reduction

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Authors

  • H F Escobar-Morreale

  • J L S Millán

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