Acanthosis nigricans as an indicator of insulin resistance in Chilean adult population

  • Pinheiro A
  • Rojas P
  • Carrasco F
 et al. 
  • 22

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Abstract

BACKGROUND: Insulin resistance (IR) is associated with a higher risk of multiple diseases and its early detection would allow to minimize the associated risk; the presence of acanthosis nigricans (AN) it's associated to the presence of IR. OBJECTIVE: To evaluate the sensibility and specificity of AN to diagnose IR in a group of Chilean patients. METHODS: We designed a cross-sectional study and it was included subjects that were attended at the Center for the Attention of Metabolic Diseases at the Faculty of Medicine, University of Chile. Sixty subjects (18-60 years age) were included. It was determined BMI and diagnosed AN and skin phototype; blood samples were taken and calculated the HOMA-IR. The normality of the variables where analyzed by Kolmogorov-Smirnov test. There were used chi(2) and the diagnostic concordance between AN and IR was determined using the Kappa index and Pearson's correlation. Sensibility, specificity, positive and negative predictive value were calculated and accepted p

Author-supplied keywords

  • Acanthosis Nigricans/diagnosis/*physiopathology
  • Adolescent
  • Adult
  • Anthropometry
  • Body Mass Index
  • Chile
  • Color
  • Cross-Sectional Studies
  • Female
  • Humans
  • Insulin Resistance/*physiology
  • Male
  • Middle Aged
  • Obesity/complications/epidemiology
  • Overweight/complications/epidemiology
  • Predictive Value of Tests
  • Retrospective Studies
  • Skin Physiological Phenomena
  • Young Adult

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Authors

  • A C Pinheiro

  • P Rojas

  • F Carrasco

  • P Gomez

  • N Mayas

  • I Morales

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