Accelerated Partial Breast Irradiation: What is Dosimetric Effect of Advanced Technology Approaches?

  • Moran J
  • Ben-David M
  • Marsh R
 et al. 
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Purpose: The present treatment planning study compared whole breast radiotherapy (WBRT) to accelerated partial breast irradiation (APBI) for different external beam techniques and geometries (e.g., free breathing [FB] and deep inspiration breath hold [DIBH]). Methods and Materials: After approval by our institutional review board, a treatment planning study was performed of 10 patients with left-sided Stage 0-I breast cancer enrolled in a Phase I-II study of APBI using intensity-modulated radiotherapy (IMRT). After lumpectomy, patients underwent planning computed tomography scans during FB and using an active breathing control device at DIBH. For the FB geometry, standard WBRT and three-dimensional conformal radiotherapy (3D-CRT) APBI plans were created. For the DIBH geometry with active breathing control, WBRT, 3D-CRT, and IMRT APBI plans were created. Results: All APBI techniques had excellent planning target volume coverage. The maximal planning target volume dose was reduced from 116% of the prescription dose to 108% with the IMRT(DIBH) APBI plan. The maximal heart dose was >30 Gy for the WBRT techniques, 8.2 Gy for 3D-CRT(FB), and

Author-supplied keywords

  • Radiation planning
  • active breathing control
  • breast cancer
  • heart
  • respiratory motion

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  • Jean M. Moran

  • Merav A. Ben-David

  • Robin B. Marsh

  • James M. Balter

  • Kent A. Griffith

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